Preoperative Chemotherapy, NSABP Protocols B-18 and B-27: an ...
Preoperative Chemotherapy, NSABP Protocols B-18 and B-27: an ... Preoperative Chemotherapy, NSABP Protocols B-18 and B-27: an ...
% Disease-Free 0 20 40 60 80 100 #N % 0 47 1-3 32 4-9 16 10+ 5 B-27 DFS no pCR and Nodes (1881) 0 2 4 6 8 Years after Randomization 0 1-3 4-9 10+
Txt Resp Txt Non-R N=24 Txt 100mg/m 2 q3w x 4 92 genes correlated with Txt response (p=0·001) Jenny Chang Lancet 362 ’03
- Page 1: Preoperative Chemotherapy, NSABP Pr
- Page 5 and 6: B-18 Duration: 88-93 ACCRUAL: 1,523
- Page 7 and 8: NSABP B-18 OPENED: Oct. 1988 CLOSED
- Page 9 and 10: Tumor Response
- Page 11 and 12: 100% 80% 60% 40% 20% 0% Tumor Respo
- Page 13 and 14: 100% 80% 60% 40% 20% 0% 42 Nodal Re
- Page 15 and 16: Outcome
- Page 17 and 18: 100 90 80 70 60 50 40 30 DFS N Ev H
- Page 19 and 20: 100 90 80 70 60 50 40 30 Survival N
- Page 21 and 22: 100 90 80 70 60 50 40 30
- Page 23 and 24: pCR and Outcome
- Page 25 and 26: 100 90 80 70 60 50 40 30 N Ev HR No
- Page 27 and 28: RESPONDERS AC chemotherapy NON RESP
- Page 29 and 30: NSABP B-27 OPENED: Dec. 1995 CLOSED
- Page 31 and 32: Tumor Response
- Page 33 and 34: 40% 20% 0% Path Complete Response 1
- Page 35 and 36: 40% 20% 0% pCR: AC→T 26 26 28 29
- Page 37 and 38: % Node + 70 60 50 40 30 20 10 0 pCR
- Page 39 and 40: 100 90 80 70 60 50 40 DFS N Ev RR P
- Page 41 and 42: 15 10 5 0 Local or IBTR AC AC→T p
- Page 43 and 44: pCR and Outcome
- Page 45: 100 90 80 70 60 50 40 pCR v no pCR
- Page 49: O p e r a b l e B C R AC X 4 AC X 4
Txt Resp<br />
Txt Non-R<br />
N=24<br />
Txt 100mg/m 2 q3w x 4<br />
92 genes correlated<br />
with Txt response<br />
(p=0·001)<br />
Jenny Ch<strong>an</strong>g<br />
L<strong>an</strong>cet 362 ’03
Change language