Clinical Trials and Preclinical Infrastructure Asset Map - Genome BC

CLINICAL TRIALS AND PRECLINICAL INFRASTRUCTURE ASSET MAP
Biomarker Translation and Development
B.C. has a large cohort of researchers who are identifying biomarkers of disease such as cardiovascular
events, cancer, CNS and pulmonary diseases, infection, and transplant rejection, and translating these
to clinical use. The key institutions involved in biomarker translation and development are listed in Table
11. Information on each of these centres can be found in Appendix 9 (sections 3, 5, 7, and 13). Of the
more than 2,100 trials included in this report, 27 (funded with over $1M) involved the translation of
biomarkers.
TABLE 11. Centres Involved in the Translation and Development of Biomarkers
Centre (URL) Biomarker Translation and Development
B.C. Cancer Research Centre (www. Diagnostic, prognostic, and predictive tests for cancer using biomarkers. Research
bccrc.ca)
depts. involved in such development include the Terry Fox Laboratory and Michael
Smith Genome Sciences Centre.
Centre for Molecular Medicine and Genetic markers that are predictive of severe ADRs for use in diagnostic screening
Therapeutics (www.cmmt.ubc.ca)
programs; genetic markers of Huntington’s Disease.
Centre for Translational and Applied
Genomics (CTAG) (www.phsa.ca/AgenciesAndServices/Services/PHSA-Labs/
About-PHSA-Labs/CTAG.htm)
Diagnostics and prognostics for cancer, infectious diseases, and inherited syndromes.
James Hogg iCAPTURE Centre (Heart Licensed out unique single nucleotide polymorphisms that can predict whether a
Lung Institute) (www.iCapture.ubc.ca) patient with sepsis will respond to certain treatments; these are being used in the
development of a molecular diagnostic test.
Prevention of Organ Failure Centre of
Excellence (PROOF) (www.proof.hli.ubc.ca)
Blood biomarkers that can identify whether a transplanted organ is being rejected.
Pharmaceutical Outcomes and Policy Involved in the identification and translation of biomarkers predictive for drug
Innovations, B.C. Children’s Hospital
(POPi) (www.popi.ubc.ca)
adverse reactions.
The Vancouver Prostate Centre PC- Development of microarrays and next generation sequencing technologies for use as
TRIADD (www.pctriadd.com)
cancer diagnostics and prognostics.
Networks
Provincial networks have been established to leverage expertise within individual B.C. institutions. These
have produced broad-based capabilities that are a lot more than the sum of the parts. The 13 networks
listed in Table 12 support clinical studies.
TABLE 12. Provincial Networks That Support Clinical Trials
Network (URL)
Disease-Based
Description
B.C. Mental Health and Addictions Builds research capacity and generates research that informs policy and practice in
Research Network (www.mhanet.ca) the field of mental health.
B.C. Pediatric Oncology Network (www. Enhances the community care of children and families by bringing multidisciplinary
bccancer.bc.ca/HPI/CancerManagement- teams together to diagnose, manage, and follow-up pediatric patients with malig-
Guidelines/Pediatric/default.htm)
nancies and blood disorders.
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