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SESSION 6: FUTURE CHALLENGE FOR EUROPE AND WORLWIDE
Dermatologic infections by Fusarium species in a
tropical clinic
A. D. van Diepeningen 1 , P. Feng 1,2 , S. Ahmed 1 , M. Sudhadham 3 , S.
Bunyaratavej 7 , G. S. de Hoog 1,5,6,7
1 CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherland; 2 The third affiliated hospital of Sun
Yat-Sen University, Sun-Yat Sen University, Guangzhou, China; 3 Suansunandharajabhat University,
Bangkok, Thailand; 4 Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
5 Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the
Netherlands; 6 Peking University Health Science Center, Research Center for Medical Mycology,
Beijing, China; 7 Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Biology, Faculty of Science and Technology,
E-mail: a.diepeningen@cbs.knaw.nl
In a set of 464 fungal isolates from a dermatological ward in Thailand, forty-four
strains (9.5%) proved to be Fusarium spp. The affiliated clinical diagnoses of the
Fusarium infections ranged were onychomycosis (61%) or other infections of nail
and skin. Multilocus DNA sequence-based genotyping of the infections was done
based on partial sequences of Elongation factor 1-apha (EF1-alpha), the internal
transcribed spacer (ITS) and RNA dependent polymerase subunit II (RPB2). The
analysis revealed that 94% of the isolates belonged to the Fusarium solani
species complex (FSSC), only one strain matched with the Fusarium oxysporum
(FOSC) complex 33, while six others belonged to the Fusarium incarnatumequiseti
species complex (FIESC). No members of the Giberella fujikuroi Species
Complex (GFSC) were detected. Especially within the FSSC different sequence
types could be recognized; one cluster being similar to Fusarium falciforme
(previously known as Acremonium falciforme). We discuss the results of our
dermatological study in comparison to previous similar studies in tropical and
moderate areas: different species complexes and different ratios between species
complexes were observed. Furthermore, in our study we saw approximately equal
numbers of male and female patients, while in the other studies infections in
women were prevalent.
Keywords: Fusarium solani species complex, Fusariosis, Onychomycosis
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