EFS12- Book of abstracts - Contact
EFS12- Book of abstracts - Contact
EFS12- Book of abstracts - Contact
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SESSION 6: FUTURE CHALLENGE FOR EUROPE AND WORLWIDE<br />
Dermatologic infections by Fusarium species in a<br />
tropical clinic<br />
A. D. van Diepeningen 1 , P. Feng 1,2 , S. Ahmed 1 , M. Sudhadham 3 , S.<br />
Bunyaratavej 7 , G. S. de Hoog 1,5,6,7<br />
1 CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherland; 2 The third affiliated hospital <strong>of</strong> Sun<br />
Yat-Sen University, Sun-Yat Sen University, Guangzhou, China; 3 Suansunandharajabhat University,<br />
Bangkok, Thailand; 4 Faculty <strong>of</strong> Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;<br />
5 Institute <strong>of</strong> Biodiversity and Ecosystem Dynamics, University <strong>of</strong> Amsterdam, Amsterdam, the<br />
Netherlands; 6 Peking University Health Science Center, Research Center for Medical Mycology,<br />
Beijing, China; 7 Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br />
Department <strong>of</strong> Biology, Faculty <strong>of</strong> Science and Technology,<br />
E-mail: a.diepeningen@cbs.knaw.nl<br />
In a set <strong>of</strong> 464 fungal isolates from a dermatological ward in Thailand, forty-four<br />
strains (9.5%) proved to be Fusarium spp. The affiliated clinical diagnoses <strong>of</strong> the<br />
Fusarium infections ranged were onychomycosis (61%) or other infections <strong>of</strong> nail<br />
and skin. Multilocus DNA sequence-based genotyping <strong>of</strong> the infections was done<br />
based on partial sequences <strong>of</strong> Elongation factor 1-apha (EF1-alpha), the internal<br />
transcribed spacer (ITS) and RNA dependent polymerase subunit II (RPB2). The<br />
analysis revealed that 94% <strong>of</strong> the isolates belonged to the Fusarium solani<br />
species complex (FSSC), only one strain matched with the Fusarium oxysporum<br />
(FOSC) complex 33, while six others belonged to the Fusarium incarnatumequiseti<br />
species complex (FIESC). No members <strong>of</strong> the Giberella fujikuroi Species<br />
Complex (GFSC) were detected. Especially within the FSSC different sequence<br />
types could be recognized; one cluster being similar to Fusarium falciforme<br />
(previously known as Acremonium falciforme). We discuss the results <strong>of</strong> our<br />
dermatological study in comparison to previous similar studies in tropical and<br />
moderate areas: different species complexes and different ratios between species<br />
complexes were observed. Furthermore, in our study we saw approximately equal<br />
numbers <strong>of</strong> male and female patients, while in the other studies infections in<br />
women were prevalent.<br />
Keywords: Fusarium solani species complex, Fusariosis, Onychomycosis<br />
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