Présentation CRB-anim [Mode de compatibilité] - Inra

Bruno Clément
bruno.clement@inserm.fr
http://crbfrance.fr/

Patients
Microorganisms
Animal and plant resources
Annotated
and validated
biological resources
Knowledge
Health
Agronomy
Model
systems
Genomics, proteomics,
metabolomics, HTS…
Data bases
bioinformatics
systems biology
Economical and
societal output
Basic
research

1999 Loi sur l’Innovation du 12 Juillet 1999 OCDE : définition des CRB
2001 Comité Consultatif des Ressources Biologiques Recommandations de l’OCDE pour les CRB,
approuvées par 30 pays
2001
à
2003
Centres de ressources biologiques
- AAP de l’INSERM, CNRS, INRA, IFREMER, BRG…
- Plan d’action du Ministère de la Santé pour les
tumorothèques
- Création du réseau national des biobanques (Inserm)
2003 Plan Cancer
=> action ciblée sur les tumorothèques par l’INCa
Déclaration de l’Unesco
2004 Loi de bioéthique du 6 août 2004
OCDE Conseil des ministres
Loi Santé Publique du 9 août 2004 => réseau global des CRB
2006 ANR : AO pour une norme française CRB Recommandations du Conseil de l’Europe
Directives européennes 2006-17 2006-86
2007 Recommandations de l’INCa pour les tumorothèques - OCDE : Guide des bonnes pratiques pour les CRB
d’origine humaine et microbienne
- ESFRI : Biobanking and Biomolecular Research
Infrastructure (20 pays, 50 institutions)
2008 - Très Grande Infrastructure de Recherche
- Publication de la Norme française NF S 96-900
- Intégration du réseau des CRB au GIS Infrastructures
en Biologie, Santé et Agronomie
2010-11 - Extension de la Norme NF S 96-900
- Investissements d’Avenir : Infrastructures en Biologie
et Santé

BBMRI MIRRI GBIFF
Réseau national
des biobanques
Tumorothèques
Santé Microorganismes Agronomie
Comité Consultatif des Ressources Biologiques
Infrastructures en Biologie, Santé et Agronomie
http://www.ibisa.net

63 Biological resources centers
Animal and plant resources 9
Micro-organisms 7
Human health 47
Infrastructures en Biologie, Santé et Agronomie
http://www.ibisa.net
Eligibility criteria
Strategic importance
Governance
Quality assurance
Information system
Access
Activity

Typology of biobanks
Non-transformed biological samples
cells, tissues, blood, stools, urine…..
Derived products:
Cells
Tissue slices
DNA, RNA…
Proteins…..
Local biobanks, mono- ou multithematic
Networked biobanks, monothematic

Examples of biobanking networks
Transient biobanking networks
• International Cancer Genome Consortium
– To describe genomic, transcriptomic and epigenomic
changes in 50 different tumor types and/or subtypes
• Human Genome Project
– To specify a reference sequence (~10 libraries)
• 1000 Genomes Project
– To describe sequence variation
• International Human Epigenome Consortium
– To describe >1000 epigenomes
• Wellcome Trust Case Control Consortium
– To discover common SNPs in common disease
• IMI U-biopred
– To discover omic biomarkers in asthma
• Japan Biobank
– To accrue rapidly 300,000 samples for genetics and
pharmacogenetics in 50+ diseases
Network infrastructures
• BBMRI : Biobank and BioMolecular
resources Research Infrastructure
– To link national biobanking initiatives
• UK DNA Banking Network
– To add scientific value to MRC genetic collections
• German biobanking platform
– To link national centres of excellence
• French biobanques Infrastructure
• To link all biological resource centres
• Spanish Biobanks infrastructure
– To link all biological resource centres
• BBMRI.se (Sweden)
– national large-scale biobanking facility
• String of Pearls Initiative
– To accrue samples in 9 diseases from 8 NL
hospitals

Objectives
• Access to samples and associated data
• Common services
• Biobank supports
– Regulatory affairs and ethics
– Methodology, biostatistics
– Technological development
• Public/private partnerships
• Links with European infrastructures: BBMRI and MIRRI
• Coordination with other PIA and related projects

Actors
75 biobanks and biological resources centers
~400 research teams
Institutions : AVIESAN…
Industry: ARIIS, equipments, IT…
Bioclusters: Medicen, LyonBiopôle, EuroBiomed, Alsace Biovalley
Coordination : Inserm
Coordinator : Georges Dagher
Scientific director: Bruno Clément
Scientific counsellor: Chantal Bizet

Scientific
Advisory Board
BBMRI
ERIC
Preparatory phase
2012-2016
Governance Council
Coordination
committee
Biobank Biobank
BRC
Stakeholders
forum
EMbaRC/
MIRRI

• 7 working groups
– Data bases and interoperability
– Quality assurance
Preparatory phase
2012-2016
– Ethical, legal and societal issues
– Technological developments
– Methodology, Statistics
– Public-Private partnerships
– Training
Budget : 11 M€

Operational phase
2016-2020
Common services
• On-step access to biological resources
• Platform « Quality-assurance, Biosecurity, Biosafety »
• Platform « Regulatory affairs and ethics »
• Platform « Methodology and biostatistics »
• Platform « Innovative technology »
• Biomarker validation unit
• Interoperability of data bases ; biocomputing
• Training
Budget : 6 M€

• Evaluation of biobanks
• Links with other PIA
F-CRIN, IHU, Labex
Sustainability
RADICO, Constance, Canto, OFSep, CKD Rein, Perinat
Metagenopolis
IFB-core
• European integration
BBMRI-ERIC, MIRRI
Collaboration UE-Chine ; UE-USA ; UE-Emirats Unis ; UE-Australie
• Financing
Biobank activities
Regional funding
European funding: Bioshare, IMI, Eucolex, Itfom

Biobanks
Are they REALLY useful for the R&D ?

Sustainability
Governance
Shared and common platforms
Strategic perspectives
Top clinics Top biobanks Top science Evaluation
Thematics
Expertise
Collections of biological samples from multicentre cohort of clinically welldefined
patients with a high level of QA and annotations
Partnerships and valorization of biological resources => Expert centers

Hospital
Patients
Samples
Med. data
Expertise
Cost recov.
Public
(not-for-profit)
Biobank
Expert Centers
Samples
Med. data
Expertise
Data
Cost recov.
Expert
Centers
Public-Private
pre-competitive
(not-for-profit)
Research data
Expertise
Expertise
In-kind
Cost recov.
Provides efficient access to samples, data and expertise
Mutual benefit from expertise and in-kind contributions
Joint generation of pre-competitive data and knowledge
Reduces requirements for sample shipment
Gateway for global collaborations
Private
competitive
(for-profit)
Industry

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