The Structure of the Cell Membrane Resting Membrane Potential

Donnan rule of equilibrium
• Diffusible ions: K + , Cl -
• In equlibrium the elektro-chemical potentials are equal.
RT
zF
[ Kin
]
[ K ]
ln = E =
out
[ in ]
[ K ]
K =
out
RT
zF
ln
[ Clout
]
[ Cl ]
in
[ Clout
]
[ Cl ]
[ K ][ Cl ] = [ K ][ Cl ]
in
in
The Donnan rule is valid only when the ions are passively distributed.!
The Gibbs–Donnan equilibrium is a phenomenon that contributes to the formation of
an electrical potential across a cell membrane.
out
out
in