The Structure of the Cell Membrane Resting Membrane Potential

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Bernstein’s potassium hypothesis (1902) Julius Bernstein (1839 - 1917) - German physiologist 1./ The cell membrane is selectively permeable to potassium • Ca2+ sensitive potassium channels • Inwardly rectifying potassium channels • Voltage-gated potassium channels • “Tandem pore domain potassium channel” – “leak channel” (K2p) ̶ 1952: Hodgkin and Huxley suggested the leakage of current ̶ etchum, KA; Joiner, WJ; Sellers, AJ; Kaczmarek, LK; Goldstein, SA. (1995) A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature, 376 (6542): 690-5. 2./ The intracellular potassium cc. is high 3./ The extracellular potassium cc. is low Bernstein,J.(1902).Untersuchungen zur Thermodynamik der bioelektrischen Strome. Pflugers Arch.ges. Physiol. 92, 521–562.
Bernstein’s potassium hypothesis K + : 100 mM Cl - : 100 mM K + : 5 mM Cl - : 5 mM
Page 1 and 2: The Structure of the Cell Membrane
Page 3 and 4: Irving Langmuir 1881 - 1957 America
Page 6 and 7: Lipid bilayer • twice as much lip
Page 8 and 9: Structure of the cell membrane Flip
Page 10 and 11: The main components of the intra- a
Page 12 and 13: Ionic concentrations inside and out
Page 14 and 15: Electrical potential ● Electric p
Page 18 and 19: Bernstein’s potassium hypothesis
Page 20 and 21: Walther Hermann Nernst German physi
Page 22 and 23: Equlibrium (resting) condition NzFE
Page 24 and 25: Nernst equation E = RT zF ln X −
Page 26 and 27: What happens if the cell membrane i
Page 29 and 30: Donnan rule of equilibrium • Diff
Page 31 and 32: Goldman-Hodgkin-Katz Constant field
Page 33 and 34: Goldman equation The membrane poten

The Structure of the Cell Membrane Resting Membrane Potential

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