The Structure of the Cell Membrane Resting Membrane Potential
The Structure of the Cell Membrane Resting Membrane Potential
The Structure of the Cell Membrane Resting Membrane Potential
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Bernstein’s potassium<br />
hypo<strong>the</strong>sis (1902)<br />
Julius Bernstein (1839 - 1917) - German physiologist<br />
1./ <strong>The</strong> cell membrane is selectively permeable to potassium<br />
• Ca2+ sensitive potassium channels<br />
• Inwardly rectifying potassium channels<br />
• Voltage-gated potassium channels<br />
• “Tandem pore domain potassium channel” – “leak channel” (K2p)<br />
̶ 1952: Hodgkin and Huxley suggested <strong>the</strong> leakage <strong>of</strong> current<br />
̶ etchum, KA; Joiner, WJ; Sellers, AJ; Kaczmarek, LK; Goldstein, SA. (1995) A<br />
new family <strong>of</strong> outwardly rectifying potassium channel proteins with two pore<br />
domains in tandem. Nature, 376 (6542): 690-5.<br />
2./ <strong>The</strong> intracellular potassium cc. is high<br />
3./ <strong>The</strong> extracellular potassium cc. is low<br />
Bernstein,J.(1902).Untersuchungen zur <strong>The</strong>rmodynamik der bioelektrischen Strome. Pflugers Arch.ges. Physiol. 92, 521–562.
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