Untitled

Water for the CIP System 47
FIGURE 5 Point-of-use valve assembly
at CIP skid: Hot WFI loop, automated
valve (interlocked), integral sample
valve, flow restriction orifice. Source:
Courtesy of Human Genome Sciences,
Rockville, Maryland, U.S.A.
personnel use will need to be considered. Large storage tanks, pumps, and piping
diameters should be considered for supplying the higher flow rates required by
CIP systems (Fig. 7). Ifthe other users of these water systems are considerably
smaller, itmay be advisable to use adedicated branch or loop that feeds the CIP
skids from alarger pump that can adjust to the large variations in flow demand.
Min
Min
Min
Process
equipment
Compendial water
distribution loop
Clean gas
or clean steam
Drain /Steam trap
/Sample point
Process
equipment
Connection
Min
Min
Process
equipment
Compendial water
distribution loop
Sample point
FIGURE 6 Point-of-use valve assembly. Courtesy of American Society of Mechanical Engineers
Bioprocessing Equipment (ASME BPE)-2005.