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Project Planning for CIPable Facility 35
FIGURE 6 An orthographic drawing of area containing process and CIP system piping installed in
gray space for ease of maintenance. Source: Courtesy of Genentech, Inc.
in purchasing such equipment from vendors that have the best experience, and
perhaps agood previous track record. It is not advisable to make purchasing
decisions solely on cost which is especially true with CIP equipment.
Spray devices for custom biopharmaceutical or pharmaceutical processes
tanks require spray coverage verification which require custom design of every
spray to ensure coverage of all tank nozzles. Procurement isbest accomplished by
providing the A&E guidance about tank top piping criteria, following the establishment
of nozzle locations for vessel procurement, and then submitting the tank head
drawings with arequest for adesign/fabricate bid from aselected spray ball
vendor. The spray balls can then be sent to the vessel vendor for spray coverage
testing in the tank shop. Neither spray device design nor spray flow rate decisions
can be made by tank fabricators unfamiliar with the total project CIP concept.
Vessels must be sprayed at aspecified flow rate and pressure which is compatible
with the CIP S/R piping design and ensures compliance with cleaning flow velocity
criteria for each tank.
Standardization of pumps, valves, and instrumentation on CIP skids is
beneficial from both procurement and long-term maintenance perspectives. This
can be accomplished by including apreferred component and instrument list with
requests for bids for skids. Consideration of lead time is important and it is
desirable to prioritize deliveries of skids, valve arrays, and transfer panels. Early
procurement ofall CIP equipment will greatly enhance the ability to finish piping