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Project Planning for CIPable Facility 27
Downstream CIP
CON pH UV
Buffer PREP Media PREP
Level 3
Buffer hold
Purification
Fermentation
Upstream CIP
CIP skid CIP skid
Harvest
Level 2
Level 1
Centrifuge
Level 0
FIGURE 3 Simplified design schematic showing all equipment cleaned by each of two CIP skids.
The final schematic would define individual circuits. Source: Courtesy of Genentech, Inc.
2. The water requirement for CIP would be 28 gal (106 L) to fill 200 0 of CIP S/R
piping, plus a3-gal (10 L) puddle in aproperly designed vessel with aflat plate
vortex breaker, and approximately 7gal (27 L) to fill 100 ft of 1.5 00 tube.
3. If the CIP skid requires only 20 gal to fill skid piping, heat exchanger, and
solution tank, then the total volume required for each recycle phase of the