Untitled

Index 387
Off skid instrumentation, 129
Operational qualification (OQ), 327
Operations, CIP facility planning
and, 38
OQ. See Operational qualification.
Overhead vapor lines, 284–285
Over-temperature alarm, problems
with, 302
Oxidizing agents, 68
Passivation, 202–210
definition of, 203
pickling, 203–204
process of, 204
repassivation, 206
surface cleanliness, 203
testing of, 206
argon electron spectroscopy
(AES), 206
electron spectroscopy for chemical
analysis (ESCA), 206
scanning electron microscopy
(SEM), 206
variables in, 204
chelants, 205
citric acid, 204–205
mineral acids, 204
welding, 205–206
Performance qualification (PQ), 327
Peristaltic pumps, 231
diaphragm type, 150
Permanent joints, fabrication of, 214
Permissive failure, 299–300
pH level,
treatment of, 318–323
value, 56
Pharmaceutical CIP systems, desirable
criteria, 115–117
Pharmaceutical Inspection Convention,
369–370
Pharmaceutical industry soils in,
54–55
Phosphates, treatment of, 323
Pickling, 203–204
PID. See proportional integral derivative.
Piping circuit, 11–12
Piping design, API processing and, 291
Piping layout, 33–34
Piping systems, 175–193
eductor
[Piping systems]
assisted pumped return flow,
179–180
return flow, 178–179
flow distribution control, 180–187
hydraulic considerations, 191–193
installation considerations, 189–191
integration of, 187–189
pumped return flow, 177–178
return flow motivation, 175–180
slope, 217
top pressure return flow, 180
Piping, flexible, 217–218
Pitting corrosion, 197
Plan commissioning, CIP system, 327–345
Plan commissioning and qualification
functional testing planning, 335–341
requirement review, 328–333
cleaning validation, 328–329
operating parameters, 329
schematics, 329–333
responsible party, 328
test documentation, 341–342
testing execution, 342–345
Plating, 213–214
PLC. See Programmable logic controller
Policy, cleaning validation, 349
Polished finishes, 199–200
types, 200–201
glass beading, 201–202
mechanical, 201
vibratory, 201
Polishes, mechanical, 213
Polishing, cost of, 200
Port arrangements, transfer panels and,
218–219
Portable CIP skid, 114–115
Portable piping systems, 175
Position sensing, valves and, 223
Post-acid rinse, 11
Post-wash rinse, 11
PQ. See Performance qualification
Pressure limitations, 216
Pressure, gas blow and, 81
Prewash rinse, 10
CIP skids, 10
water type, 10
Process applications, mix proof valves,
238–244
Process component addition, 12–12