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382
[CIPable facility project planning]
project planning, life cycle, 23
schematic development, 26
special cleaning regimes, 31
trend CIP circuit performance
report, 38
validation, 37–38
CIPable integrated design, 22
CIPable process, components of, 2–8
automated skid, 7
AWFI supply, 8
bypass line, 7
CIP supply piping, 7
CIPR
flush valve, 7
pump, 7
transfer line, 6–7
U-bend transport panels, 4–6
vessels, 2–4
water supply, 8
CIPR. See CIP return piping.
CIPS to circuit, 104–105
CIPS. See CIP supply.
Circuit dirty hold time, 312–313
Circuit flushing, 339–340
Circuit hydraulic balance, troubleshooting
of, 310–312
CIP recirculation tank, 310–311
Circuit recipe parameters, 312
Citric acid, 204
Clamp-type connections, 215
Clean hold expiration times, 91
Clean-in-place. See CIP.
Clean surface, passivation and, 203
Cleanable API processing, equipment
and systems, 275–295
Cleanable in-line components, 211–234
fabrication, 214–217
flexible hoses and piping, 217–218
instruments, 231–233
interior surfaces, 213–214
electropolish, 213
mechanical polishes, 213
plating, 213–214
pumps, 228–231
standards
developing organizations, 211–212
guidelines, 212–213
transfer panels, 218–221
valves, 222–228
Index
Cleanable liquids processing
design criteria, 235–236
automated valves, 236
flexibility vs. automation, 235–236
flexible tubing, 236
transfer panels, 236
equipment and systems, 235–255
process applications, 236–253
mixproof valves, 238–244
process trains, 236–238
steam-in-place, 253–254
Cleaned out-of-place (COP), 1
manual cleaning, 15–16
Cleaning agent constituents, 58–69
builders, 58–59
chelating agents, 64–66
corrosion inhibitors, 69
defoamer, 66–68
environmental effects of, 70–71
oxidizing, 68
sequestering agents, 66
surfactants, 59–64
Cleaning agent injection systems, 145–158
chemical feed methods, 149–153
safe chemical storage and handling,
145–148
solution dilution, 153–158
Cleaning agent residue limits, 351–353
Cleaning agent solution dilution, 153–158
concentration and residue removal
verification, 157–158
mixing and control, 155
single-pass cleaning, 156–157
slipsteam method, 153–154
Cleaning agents
alkaline, 57–58
choosing of, 71–72
cleaning process, 53–54
composition of, 53–72
detergents, 55–58
method development, 55
pH value, 56
soils, 54–55
Cleaning circuits, glass-lined reactor
systems and, 286–288
Cleaning cycles, 29, 288–289
Cleaning cycle sequences, 73–91
CIP program
parameters, 77–79
phases, 74–75