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330<br />

in order to complete the intended study.However,more appropriate solutions were<br />

desired for long-term production. ACIP consultant was hired to redesign and<br />

commission the modified system prior to the next production phase.<br />

The next production phase was for process validation for adifferent portion<br />

of the process. It involved 10 different CIP circuits. Iwill refer to this as Project B.<br />

The remaining production process steps and circuits would be validated later.<br />

Cleaning validation activities were performed for both Projects A and B. For<br />

Project B, Iwas involved with the preparation of software functional requirements,<br />

but was not involved for the majority of the commissioning. Iwas consulted<br />

to help troubleshoot issues with the system after the consultant completed its<br />

commissioning.<br />

Skid and Circuit Schematic Design<br />

Atypical CIP circuit is shown in Figure 1. Aschematic of aCIP skid is shown in<br />

Figure 2. Following is the description of atypical CIP operation. (This is the way the<br />

systems for Project Bwork):<br />

1. ACIP circuit consists of the CIP skid, the process vessel and process piping, and<br />

the CIP supply and return piping.<br />

2. The CIP system and process systems are controlled by the same distributed<br />

control system (DCS).<br />

3. There are anumber of transfer panels and valve clusters used throughout the<br />

distribution system.<br />

CIP supply<br />

valve manifold<br />

CIP supply<br />

pump<br />

Chemicals<br />

Fresh water<br />

CIP tank<br />

Tank Atop<br />

valve manifold<br />

FIGURE 1 Atypical CIP circuit.<br />

CIP return<br />

valve manifold<br />

Once-through<br />

rinse byepass<br />

Process<br />

inlet<br />

Tank Abottom<br />

valve manifold<br />

Tank Btop<br />

valve manifold<br />

Spray<br />

ball<br />

Tank A Tank B<br />

Sample<br />

flush<br />

Tank Atotank B<br />

Transfer line<br />

Norton

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