Untitled

286
3" Stub end
w/150# flange
2A
1
3
Plan view
2B
FIGURE 5 Instrument holder connections.
Solids Charge Nozzles/Chutes
Solids charge nozzles and chutes can be achallenge to clean. By their nature they are
always heavily soiled after use. They can, however,becleaned like vertical tanks by
applying falling films of CIP solution, initiated from properly positioned bubbletype
sprays.
The use of asplit butterfly valve for contained solids transfers has become
quite popular in bulk pharmaceutical processing. Vendors of these devices offer
special adaptors fitted with spray devices that allow for CIP of their solids
handling valves.
REACTOR CLEANING CIRCUITS
As previously stated, in the design of API CIP systems, it should be agoal of the
designer to use as much of the process piping and equipment as possible to
distribute the cleaning solution.
& Thereisalong-standing “rule of thumb” that lines should be flushed at arate of
5ft/sec. This rule of thumb was developed by early workers with CIP systems
comprised primarily of glass pipe. Simple observations of flow in lines of 1 1 ⁄ 2 to
3in. in diameter, inextensive circuits, indicated the need for a5ft/sec velocity
to ensure that the flow is highly turbulent and will sweep air from long
horizontal runs, that it will flood vertical runs in adownflow regime, and
that it will sweep gas pockets out of vertical tees.
Obtaining 5ft/sec is not always possible, but this is agood starting point for
evaluating the system. The designer is usually confronted with the fact that the
system uses Teflon-lined pipe of four different sizes, as shown in Table 3.
In the design of reactor systems between 300 and 4000 gal, the most typical
liquid transfer line is generally 2in. Consequently, there is an upper limit to how
much liquid can be distributed at any one time because of the limitations of the
piping components and the characteristics of the process transfer pump.
8"I.d.
Side view
1
3
Tube spray
2A 2B
Temperature
probe
1-1/2" Stub end
w/150# flange
Two -3"stub ends
w/150# flanges
Cerulli
Pressure
instruments
with seals