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Nozzle
Use
A Manway
B Agitator
C CIP/Liquid feed
D Sample dip pipe
E Vapor rizer
F Liquid inlet
G CIP
H Solid charge
I Baffle
J Liquid inlet
K CIP/Liquid feed
FIGURE 3 The 2000-gallon vessel top head.
E
D
F
to assurefull coverage, the need can be alleviated if the nozzle is externally flushed
as part of the line cleaning. Examples of externally flushed nozzles include all
liquid feeds, reflux, and the vapor riser.Shorter neck nozzles are easier to spray and
should be favored in the design stage if they can be fabricated by the vessel vendor.
In the past, the baffle nozzle has been aproblem. Typically,this nozzle must be
cleaned by spray directed from below. This has been addressed by extending the
baffle and inserting aglass-lined instrument tee to allow for CIP fluid to be injected
into the annulus of the baffle/temperature transmitter nozzle temperature transmitter
(TT) and level transmitter (LT) in Figure 2. This approach could be used for
any unflushed nozzle with avertical member inserted into the vessel, such as a
dip pipe.
Condensers
Avertical condenser is shown in Figure 2. Assuming the need for a 200 ft 2
condenser with 174, 3 ⁄ 4 in., tubes to achieve aflushing rate of 5ft/sec would have
required aflow of over 1200 gpm. Clearly, this is not feasible. Even with arate of
1ft/sec, the flow is much greater than that which could be provided by the process
pump. However, ifasingle-pass (i.e., process on tube side) condenser is mounted
vertically, itispossible to introduce CIP liquid at such arate that afalling film is
established in each tube. This film will consistently wet the tube surfaces and sweep
away soil continuously. Asecond smaller spray ball can be used to wet the bottom
tube sheet. This method has proven effective in cleaning reactor condensers. The
individual tubes are treated as small tanks, which need not be filled, to be effectively
wetted and cleaned.
Overhead Vapor Lines
Overhead vapor risers and reactor emergency vent piping can be the largest bore
process piping in abulk pharmaceutical facility. Typical sizes may range from 4to
6in. for a300-gallon vessel to 8to10in. for 2000-gallon reactors. It is not possible to
pressure flush such large diameter lines at rates that would achieve 3to5ft/sec.
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Cerulli