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266<br />

FIGURE 9 Pleated filter cartridges. Source: Courtesy of MikroPul, Inc.<br />

Forder<br />

Fluid Bed Dryer<br />

Fluid bed dryer and granulators use hot gases to dry and/or agglomerate dry<br />

powders. Wetproduct is sprayed into the gas stream through an atomizer or spray<br />

arm (similar to aspray dryer). Product is dried and collected in ahopper at the<br />

bottom of the dry chamber. After all liquid is sprayed into the drying chamber, the<br />

dryer is shut down and the hopper removed.<br />

Incorporation of automated cleaning can be done with fluid bed dryers and<br />

granulators. There are many advantages in being able to CIP afluid bed dryer<br />

including ensuring cleaning repeatability and consistency of the cleaning operation.<br />

Additionally, CIPable fluid bed dryers can significantly reduce exposure risk<br />

associated with operation and cleaning.<br />

Fluid Bed Dryer Design Considerations<br />

Many of the design considerations applicable to spray dryers are applicable to the<br />

fluid bed dryer. Several specific challenges exist in cleaning the fluid bed dryer.<br />

Filters are installed in the top of the drying chamber to collect exhaust particles in<br />

the drying stream. These filters are removed and washed or if of asuitable material<br />

(sintered metal, Teflon cartridge) may be cleaned in place.<br />

Again, care needs to be focused on the gasket and flange design as with<br />

spray dryers. Similar to the spray dryer, sanitary flange connections minimize the

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