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240
Seiberling
FIGURE 3 This shop-fabricated manifold, consisting of 42 mixproof, rising-stem valves, interfaced
six vessels to atransfer panel similar to Figure 2and provided CIP supply/return pure water and a
solvent, all under automated control. Source: Courtesy of Electrol Specialties Company.
These headers in turn are connected via secondary U-Bends at either end of the
panel to other processes such as fixed or portable chromatographic columns, fixed
or portable evaporators, or portable equipment in other processing suites below.All
U-Bends were proximity sensor equipped to permit verification of position,
unchanged during normal use of aprocess configured for aparticular product
development function.
Chapter 12 provides pertinent information about valve and line sizing and
design of the “looped headers” in both the transfer panels and valve groups to
minimize space, cost and product holdup, and most importantly, avoid any
deadlegs in the process piping.
Mixproof Valves in aDedicated Production Process
Figures 2–5 described aproduct development process that required amaximum
degree of flexibility in the use of the equipment. The next example is alarge-scale
production process dedicated only to buffer makeup and transfer, and supply to
two dedicated process trains that included chromatography columns. Figure 6
shows agroup of mixproof valves applied to control product flow from three
buffer/chemical preparation vessels and CIPS flow to 10 downstream hold tanks,
which in turn supported two chromatography trains.