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Cleanable Liquids Processing Equipment and Systems 239
FIGURE 2 This larger process/clean-in-place transfer panel utilized loop-type headers and two
different U-Bend lengths to configure aproduct development suite for amultiplicity of operations, all
fully automated. Source: Courtesy of Electrol Specialties Company.
to configure analternative automated process for clinical trial production. All
U-Bends were monitored by proximity sensors for validated process and CIP
requirements. Figure 3illustrates atypical rising stem mixproof valve group or
manifold used in combination with the transfer panel to control CIPS and CIPR
flow, product transfers, addition of solvents, pure water, etc., to any process vessel
in the suite. Figure 4isaplan view of the valve group that illustrates the “looped
headers” in plan and elevation view and establishes the size at approximately 3.5 ft
wide by 7ftlong, for seven valves each for eight vessels. Figure 5shows how the
valve group, vessels, and transfer panel were installed in amulti-floor process to
maximize the use of gravity to drain vessels and piping to the support suites and to
the CIP skid.
This panel is mounted on the floor beneath agroup of eight tanks on apad
with some piping continuing from the panel through the floor below to support
suites. The eight pair of lines leaving the top of the panel connected to the fill valve
of aloop for each tank and to the outlet valve of each tank. The large primary
U-Bends on this panel would connect any of the eight tanks to any of seven
fill headers, any of seven discharge headers, or to acommon transfer header.