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Lebowitz
oriented vertically. This is the least preferred orientation since an uncleanable
vertical dead-leg “trap” is created in the distance between flow traveling through
the main header and the diaphragm of the valve.
The horizontally oriented valves located above TP-3 are an acceptable
arrangement as long as the distance between the center of the main flow path
and diaphragm valve weir is less than two pipe diameters.
The preferred orientation is the zero-static type diaphragm valves located
above TP-5. In this case, the zero-static valves ensure that there isessentially no
dead leg between the main flow path and diaphragm valve weir.
CIPS and CIPR Loops
The isometric drawing of Figure 7illustrates asingle CIP system that services
various process areas in a biopharmaceutical facility. A composite of various
methods of installing CIPS and CIPR is shown in this example. All concepts
assure complete freedom offlow dead legs and provide essentially uniform
operating volumes and times for all tank CIP programs. One of the two primary
CIPS control valves located just beyond the CIP system branches toward the CIPS
header supplying MT-1 through MT-3, the remainder of the area being in
accordance with Figure 6asdescribed above. CIPR pump RP-1 discharges to a
CIPR distribution valve before the final line to the CIP skid.
Loop-type piping is shown in Figure 7for the CIPS and CIPR connections to
tanks T-4 toT-9.
Permanent product pump PP/RP, also used as aCIPR pump (which might
include variable frequency drive (VFD) variable speed capacity control), is located
at the discharge of T-5. Aportable CIPR pump (RP-2) is used for T-4and T-6(shown
connected) and apermanent CIPR pump (RP-3) on low-level transfer panel TP-10 is
used for T-7 toT-9.
An alternative “loop-type” CIPS/R concept is illustrated as the means of
providing CIPS/R capability to tanks T-4 to T-9 inclusive in several different
manners. The objective of this revised approach is twofold and includes totally
eliminating the possibility of any “dead ends” in that portion of the system in use
and providing auniform supply and return path for each of the tanks in the several
groups at various locations within the facility.
Four different methods of providing pumped return are illustrated in
Figure 7. These include the following.
1. Apermanently installed return pump RP-1 supplied by the header at vessels
MT-1 through MT-3, as described above, engineered and specified to serve the
CIP solution return need only.
2. Acentrifugal pump PP/RP installed in the discharge line of vessel T-5 and
equipped with aVFD for capacity control would be used for product transfers
and CIPR.
3. Aportable CIPR pump RP-2 would be used at tanks T-4 and T-6. This pump
would connect via ahose directly to the tank outlet valve of T-4ortothe port on
TP-9 for T-6, and via another hose to aCIPR port on TP-7 or TP-9. The suctionside
hoses must be short and installed to maintain continuous pitch upwards
from the return pump inlet to the tank outlet valve for efficient and reliable
performance of the CIP system.
4. Apermanently installed return pump RP-3 is shown as the means of returning
solution from vessels T-7toT-9, which connect to ports on TP-10. For CIPR, the