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CIP Spray Device Design and Application 171 permanent installation in the housing. To spray clean afilter housing requires a means of keeping the housing essentially empty,which is accomplished by injecting air into the CIP supply line at the beginning of each phase of the CIP program, and during periods of recirculation. This air injection approach results in the development of apocket of air in the housing, and allows the sprays to function as intended. Experimentation has demonstrated the ability to achieve flow rates of 50 gpm (190 Lpm) through a filter housing, sufficient to provide a velocity of 5fpm (1.5 m/sec) through 2-in. piping in the circuit, and upwards of 80 gpm (300 Lpm), when required, tosimultaneously clean avessel downstream ofthe filter housing, while accumulating only 1to3gal (3.8–11L)inthe housing. Aspray-type CIP device as shown in Figure 8isrequired when the filter housing has nozzle connections on the dome in addition to the spray nozzle connection. This spray provides the necessary upward vector to assure coverage in the additional dome nozzles. Alarger hole in the bottom of the machined element is sized to pass solution not required to clean the housing, and maintain operation at alow-pressure drop. Figure 9illustrates adisk distributor type CIP device applicable to any filter housing free of nozzles in the top dome. The width of the slot between the disc and the dome is based on flow rate and desired pressure drop through the housing. Figure 10 is aphoto of an experimental setup in which atest dome fitted with adisk distributor sized for 50 gpm and 5psi was rotated to discharge horizontally.The full film of water cascading off the edge of the dome projected several feet as ahollow tube of water. The flow rates and operating pressure drop for these sprays are determined by other elements of the CIP circuit when the filter housing is being cleaned with piping and adownstream vessel or other equipment. Deliberate incorporation of air in the CIP stream requires special consideration for handling the CIP return flow. Rupture disk Spray tube hole FIGURE 8 If afilter housing is fitted with nozzles in the top dome area, aspray-type device of short length and capable of being drilled for awide variety of flow and pressure requirements is used to direct streams to the multiple nozzles, as when cleaning larger vessels.
172 Franks and Seiberling FIGURE 9 Filter housings absent nozzles in the dome may be cleaned with a simple disc distributor. This device may be left in place for all use of the filter and will distribute flush, wash, and rinse solutions to the housing dome and sidewall at any range of flow and pressure required to meet other CIP design criteria. Avessel downstreamofthe filter housing will provide ameans of disengaging that air beforeitreaches astandardcentrifugal return pump. An eductor-assisted return has worked successfully in these applications and aliquid ring return pump may also be an alternative choice for this application. FIGURE 10 This photo made during developmenttesting of the disc distributorCIP device shows a hollow tube of water leaving the test dome when located in ahorizontal position.
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Clean-In-Place for Biopharmaceutica
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Informa Healthcare USA, Inc. 52 Van
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iv Preface period, the industry rec
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Preface iii Contents Acknowledgment
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Contributors Barry J. Andersen Seib
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2 the last step of abatch manufactu
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4 Seiberling The vessel capacity ma
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6 Seiberling any two ports. For pur
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8 AWFI (or Any Water) Supply If the
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10 Seiberling program, and through
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12 Seiberling (380 L) for the solut
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14 AWFI CIP skid Drain When steam a
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16 Seiberling products in asingle f
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18 Seiberling The literature began
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2 Project Planning for the CIPable
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Project Planning for CIPable Facili
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3 Water for the CIP System Jay C. A
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Water for the CIP System 43 FIGURE
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Water for the CIP System 45 of clea
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Water for the CIP System 51 WATER U
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54 Time Temperature FIGURE 2 The cl
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56 Classification of Cleaners by pH
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58 [mg/sec] Cleaning velocity C v ,
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60 + - Na O O C CH 2 CH 2 (CH 2 ) n
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62 CH3 -(CH2 ) n -CH2 -O -CH2 -CH2
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64 B C D E FIGURE 17 Capability of
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66 pH 13 pH 7 pH, %, Excess water h
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68 dramatically increased rinsing t
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70 desorption. If the affinity is v
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72 & Cleaning procedure inthe case
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74 effort being performed relativel
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76 Rush & A1000 Lmixing vessel, hav
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78 TABLE 2 Typical Single-Pass Chem
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80 Rush Rinse Volume (Duration) The
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82 Rush Intermediate Drain Objectiv
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84 Rush Final Drain Phase (Gravity)
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86 TABLE 4 Recirculated Chemical Wa
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88 Rush type of soil include fermen
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90 The pre-cleaning process flush w
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92 REFERENCES Rush 1. Howard T, Wie
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94 CIP return (CIPR)-piping to conv
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96 Seiberling provided, generally o
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98 Single-Tank CIP Skid Operational
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100 Single-Tank Bypass or Recycle O
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102 Seiberling Single-Tank Single P
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104 Seiberling installation of an e
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106 Chemical loop AB FE Chemical bl
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108 Chemical loop AB FCV FE Steam C
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CIP supply Transfer line (typical)
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112 Seiberling FIGURE 14 This singl
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114 Seiberling FIGURE 15 This large
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116 Seiberling FIGURE 17 This mini-
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7 CIP System Instrumentation and Co
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Page 164: CIP System Instrumentation and Cont
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Page 169 and 170: 148 Lebowitz barrels and the chemic
Page 171 and 172: 150 Lebowitz Electromagnetic-Operat
Page 173 and 174: 152 Lebowitz FIGURE 5 The venturi o
Page 175 and 176: 154 Chemical pump enclosure Acid AL
Page 177 and 178: 156 Steam Facility acid header Faci
Page 179 and 180: 158 Lebowitz That is to say aweak a
Page 181 and 182: 160 CIP Philosophy The production p
Page 183 and 184: 162 Franks and Seiberling the numbe
Page 185 and 186: 164 Franks and Seiberling Similar s
Page 187 and 188: 166 Franks and Seiberling FIGURE 3
Page 189 and 190: 168 Franks and Seiberling FIGURE 5
Page 191: 170 (A) (B) Franks and Seiberling F
Page 195 and 196: 174 The variables that impact the r
Page 197 and 198: 176 There are two guiding concepts
Page 199 and 200: 178 Mezz. Floor(ref.) V-5 1000L CIP
Page 201 and 202: 180 return line piping, substantial
Page 203 and 204: 182 Lebowitz U-bend transfer panels
Page 205 and 206: 184 Lebowitz oriented vertically. T
Page 207 and 208: 186 Lebowitz suction-side port on T
Page 209 and 210: CIPS loop Primary CIPS CIPSPS CIPS
Page 211 and 212: 190 Lebowitz FIGURE 10 Photo of sma
Page 213 and 214: 192 Drain CIP return Drain Recycle
Page 216 and 217: 11 Materials of Construction and Su
Page 218 and 219: Materials of Construction and Surfa
Page 232 and 233: 12 Cleanable In-Line Components INT
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Page 240 and 241: Cleanable In-Line Components 219 FI
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Cleanable In-Line Components 221 Tr
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Cleanable In-Line Components 223 it
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Cleanable In-Line Components 225 FI
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Cleanable In-Line Components 227 FI
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Cleanable In-Line Components 229 eq
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Cleanable In-Line Components 231 Th
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Cleanable In-Line Components 233 co
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13 Cleanable Liquids Processing Equ
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Cleanable Liquids Processing Equipm
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1-9 CIPS 2 Plant steam CIPS valves
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258 8. Projectile-type thermometer
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260 Forder control of the drying pr
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262 Forder FIGURE 5 Pharmaceutical
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264 Forder FIGURE 7 Pharmaceutical
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266 FIGURE 9 Pleated filter cartrid
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268 FIGURE 12 Disassembledstainless
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270 The acid wash of 85% phosphoric
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272 FIGURE 17 Sanitary Vbenders. So
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274 one each for the upper, central
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276 CIP VS. TRADITIONAL BOIL-UP MET
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278 Cerulli were not designed to be
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280 by large flanged connections fo
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282 CIP header Once thru CIP soluti
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284 Nozzle Use A Manway B Agitator
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286 3" Stub end w/150# flange 2A 1
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288 In most cases, the pressure dro
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290 CIP fluids Process fluids 1 2 3
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292 A Vent to atm. B M Conical drye
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294 One of the designer’s first t
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16 CIP System Troubleshooting Guide
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CIP System Troubleshooting Guide 29
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17 Waste Treatment for the CIP Syst
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Waste Treatment for the CIP System
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18 Commissioning and Qualification
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Commissioning and Qualification 329
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348 & Sterilization refers to the r
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350 Lankford All analytical methods
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352 should be based upon scientific
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354 Lankford acleaning validation p
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356 In summary, TOC analysis is are
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358 In-Situ In-situ measurement tec
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360 15. Karen A. Clark, Product Man
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362 Actually, most countries revise
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364 §211.100 Written procedures; d
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366 §211.186 Master production and
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368 Equipment Regulation C.02.005 T
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370 … C.02.004 … 4. Pipework sy
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372 5.20 Schedules and procedures (
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374 TABLE 1 Directives of the Europ
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376 TABLE 5 Cleanability Performanc
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Index Accessibility, 28 Acid cleane
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Index 381 CIP supply flow troublesh
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Index 383 [Cleaning cycle sequences
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Index 385 Flow alarm, no-return, 30
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Index 387 Off skid instrumentation,
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Index 389 Rising stem valves, 223-2
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Index 391 [Troubleshooting] spray c
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