Untitled

More documents

Recommendations

Info

Cleaning Agent Injection Systems 155 Alkali Acid Drain Facility waste Restrictor CIPR FCV CIPS Small diameter chemical loop Vortex meter Steam Chemical pump RTD enclosure T Motive pump AB Drain PS LS Sample CIPS pump CDV Mixing and Control of Application of Cleaning Agents From the perspective of CIP cycle optimization, the most efficient and economical method of batching CIP chemicals is by direct injection into the recirculating wash solution either in the CIP return line manifold or the recirculation tank. Following the initial pre-wash rinsing to drain at the start of the CIP program, a “system fill” volume of water is pumped into the CIP circuit adequate to fill the CIP supply/return piping, accumulate asmall “puddle” in the process tank being cleaned (if atank cleaning program is in progress), and establish aminimum working volume in the CIP recirculation tank (if arecirculation tank is being utilized). After the system fill, stable recirculation is established between the CIP system and process equipment, tanks, and piping that comprise the CIP circuit. The volume recirculating should now be the absolute minimum necessary to ensure that chemical dosing volume, heating energy, and subsequent effluent volume are all optimized to be the least possible. Heating is generally initiated at this time. Chemical cleaning agents are then injected into the recirculating system fill water volume by any of the established delivery and dilution methods to obtain the desired concentration. In this manner, when the solution is at strength and wellmixed, the solution will likewise be at set point temperature for the wash. It is desirable to inject the concentrated chemical into the recirculating solution over a long period of time, preferably during five to seven passes through the circuit, to maximize uniform distribution. If excessive feed rates are used, i.e., oversized chemical feed pumps, the only opportunity for mixing to occur is in the small puddle of avessel being cleaned and in the CIP skid solution tank. LP Water FIGURE 7 Illustration of asmall diameter chemical loop with discharge through anozzle on the head of the recirculation tank. WV1
156 Steam Facility acid header Facility alkali header CIP return CIP supply Flow meter T CIPS pump AB Drain HV4B HV4A HV3B HV2B FE HV1B By-pass return CVB Recycle V1B TOV Recirc tank HV2A Water In-Line Chemical Injection for Single-Pass Cleaning Direct in-line chemical injection for single-pass delivery is used for selected CIP applications, where adecision is made to provide single-pass chemical contact on a once-through basis rather than detergent wash recirculation. Examples of singlepass CIP are pre-CIP decontamination rinses, cleaning of atransfer line separating different classes of areas, and cleaning multi-product filling lines. The most common method of direct injection utilizes amotor-operated diaphragm pump with discharge connection to the CIP supply pump suction, either directly or through aslip-stream loop. The flow rate of amotor-operated diaphragm pump is near-linear to the speed of rotation of the drive motor. This type of pump is especially suitable when alarge dosing volume is required in proportion to an analog FE output, as in the case for single-pass chemical delivery. An alternate method for single-pass delivery is to pre-batch cleaning agent solution in aCIP recirculation tank that is located on the CIP system. The CIP recirculation tank is first filled with water. Then, local pumped recirculation is FE HV3A HV1A FIGURE 8 Illustration of direct chemical injection from apressurized header, including requisite valves and instrumentation. CVA V1A Lebowitz
Page 2:
Clean-In-Place for Biopharmaceutica
Page 13 and 14:
Informa Healthcare USA, Inc. 52 Van
Page 15 and 16:
iv Preface period, the industry rec
Page 18 and 19:
Preface iii Contents Acknowledgment
Page 20:
Contributors Barry J. Andersen Seib
Page 23 and 24:
2 the last step of abatch manufactu
Page 25 and 26:
4 Seiberling The vessel capacity ma
Page 27 and 28:
6 Seiberling any two ports. For pur
Page 29 and 30:
8 AWFI (or Any Water) Supply If the
Page 31 and 32:
10 Seiberling program, and through
Page 33 and 34:
12 Seiberling (380 L) for the solut
Page 35 and 36:
14 AWFI CIP skid Drain When steam a
Page 37 and 38:
16 Seiberling products in asingle f
Page 39 and 40:
18 Seiberling The literature began
Page 42 and 43:
2 Project Planning for the CIPable
Page 44 and 45:
Project Planning for CIPable Facili
Page 46 and 47:
Page 48 and 49:
Page 50 and 51:
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
3 Water for the CIP System Jay C. A
Page 64 and 65:
Water for the CIP System 43 FIGURE
Page 66 and 67:
Water for the CIP System 45 of clea
Page 68 and 69:
Page 70 and 71:
Page 72:
Water for the CIP System 51 WATER U
Page 75 and 76:
54 Time Temperature FIGURE 2 The cl
Page 77 and 78:
56 Classification of Cleaners by pH
Page 79 and 80:
58 [mg/sec] Cleaning velocity C v ,
Page 81 and 82:
60 + - Na O O C CH 2 CH 2 (CH 2 ) n
Page 83 and 84:
62 CH3 -(CH2 ) n -CH2 -O -CH2 -CH2
Page 85 and 86:
64 B C D E FIGURE 17 Capability of
Page 87 and 88:
66 pH 13 pH 7 pH, %, Excess water h
Page 89 and 90:
68 dramatically increased rinsing t
Page 91 and 92:
70 desorption. If the affinity is v
Page 93 and 94:
72 & Cleaning procedure inthe case
Page 95 and 96:
74 effort being performed relativel
Page 97 and 98:
76 Rush & A1000 Lmixing vessel, hav
Page 99 and 100:
78 TABLE 2 Typical Single-Pass Chem
Page 101 and 102:
80 Rush Rinse Volume (Duration) The
Page 103 and 104:
82 Rush Intermediate Drain Objectiv
Page 105 and 106:
84 Rush Final Drain Phase (Gravity)
Page 107 and 108:
86 TABLE 4 Recirculated Chemical Wa
Page 109 and 110:
88 Rush type of soil include fermen
Page 111 and 112:
90 The pre-cleaning process flush w
Page 113 and 114:
92 REFERENCES Rush 1. Howard T, Wie
Page 115 and 116:
94 CIP return (CIPR)-piping to conv
Page 117 and 118:
96 Seiberling provided, generally o
Page 119 and 120:
98 Single-Tank CIP Skid Operational
Page 121 and 122:
100 Single-Tank Bypass or Recycle O
Page 123 and 124:
102 Seiberling Single-Tank Single P
Page 125 and 126: 104 Seiberling installation of an e
Page 127 and 128: 106 Chemical loop AB FE Chemical bl
Page 129 and 130: 108 Chemical loop AB FCV FE Steam C
Page 131 and 132: CIP supply Transfer line (typical)
Page 133 and 134: 112 Seiberling FIGURE 14 This singl
Page 135 and 136: 114 Seiberling FIGURE 15 This large
Page 137 and 138: 116 Seiberling FIGURE 17 This mini-
Page 140 and 141: 7 CIP System Instrumentation and Co
Page 142 and 143: CIP System Instrumentation and Cont
Page 164: CIP System Instrumentation and Cont
Page 167 and 168: 146 Lebowitz should be considered f
Page 169 and 170: 148 Lebowitz barrels and the chemic
Page 171 and 172: 150 Lebowitz Electromagnetic-Operat
Page 173 and 174: 152 Lebowitz FIGURE 5 The venturi o
Page 175: 154 Chemical pump enclosure Acid AL
Page 179 and 180: 158 Lebowitz That is to say aweak a
Page 181 and 182: 160 CIP Philosophy The production p
Page 183 and 184: 162 Franks and Seiberling the numbe
Page 185 and 186: 164 Franks and Seiberling Similar s
Page 187 and 188: 166 Franks and Seiberling FIGURE 3
Page 191 and 192: 170 (A) (B) Franks and Seiberling F
Page 195 and 196: 174 The variables that impact the r
Page 197 and 198: 176 There are two guiding concepts
Page 199 and 200: 178 Mezz. Floor(ref.) V-5 1000L CIP
Page 201 and 202: 180 return line piping, substantial
Page 203 and 204: 182 Lebowitz U-bend transfer panels
Page 205 and 206: 184 Lebowitz oriented vertically. T
Page 207 and 208: 186 Lebowitz suction-side port on T
Page 209 and 210: CIPS loop Primary CIPS CIPSPS CIPS
Page 211 and 212: 190 Lebowitz FIGURE 10 Photo of sma
Page 213 and 214: 192 Drain CIP return Drain Recycle
Page 216 and 217: 11 Materials of Construction and Su
Page 218 and 219: Materials of Construction and Surfa
Page 226 and 227:
Materials of Construction and Surfa
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
12 Cleanable In-Line Components INT
Page 234 and 235:
Cleanable In-Line Components 213 &
Page 236 and 237:
Cleanable In-Line Components 215 Al
Page 238 and 239:
Cleanable In-Line Components 217 Ex
Page 240 and 241:
Cleanable In-Line Components 219 FI
Page 242 and 243:
Cleanable In-Line Components 221 Tr
Page 244 and 245:
Cleanable In-Line Components 223 it
Page 246 and 247:
Page 248 and 249:
Page 250 and 251:
Cleanable In-Line Components 229 eq
Page 252 and 253:
Cleanable In-Line Components 231 Th
Page 254 and 255:
Cleanable In-Line Components 233 co
Page 256 and 257:
13 Cleanable Liquids Processing Equ
Page 258 and 259:
Cleanable Liquids Processing Equipm
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
1-9 CIPS 2 Plant steam CIPS valves
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276:
Page 279 and 280:
258 8. Projectile-type thermometer
Page 281 and 282:
260 Forder control of the drying pr
Page 283 and 284:
262 Forder FIGURE 5 Pharmaceutical
Page 285 and 286:
264 Forder FIGURE 7 Pharmaceutical
Page 287 and 288:
266 FIGURE 9 Pleated filter cartrid
Page 289 and 290:
268 FIGURE 12 Disassembledstainless
Page 291 and 292:
270 The acid wash of 85% phosphoric
Page 293 and 294:
272 FIGURE 17 Sanitary Vbenders. So
Page 295 and 296:
274 one each for the upper, central
Page 297 and 298:
276 CIP VS. TRADITIONAL BOIL-UP MET
Page 299 and 300:
278 Cerulli were not designed to be
Page 301 and 302:
280 by large flanged connections fo
Page 303 and 304:
282 CIP header Once thru CIP soluti
Page 305 and 306:
284 Nozzle Use A Manway B Agitator
Page 307 and 308:
286 3" Stub end w/150# flange 2A 1
Page 309 and 310:
288 In most cases, the pressure dro
Page 311 and 312:
290 CIP fluids Process fluids 1 2 3
Page 313 and 314:
292 A Vent to atm. B M Conical drye
Page 315 and 316:
294 One of the designer’s first t
Page 318 and 319:
16 CIP System Troubleshooting Guide
Page 320 and 321:
CIP System Troubleshooting Guide 29
Page 322 and 323:
Page 324 and 325:
Page 326 and 327:
Page 328 and 329:
Page 330 and 331:
Page 332 and 333:
Page 334 and 335:
Page 336 and 337:
17 Waste Treatment for the CIP Syst
Page 338 and 339:
Waste Treatment for the CIP System
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
18 Commissioning and Qualification
Page 350 and 351:
Commissioning and Qualification 329
Page 352 and 353:
Page 354 and 355:
Page 356 and 357:
Page 358 and 359:
Page 360 and 361:
Page 362 and 363:
Page 364 and 365:
Page 366:
Page 369 and 370:
348 & Sterilization refers to the r
Page 371 and 372:
350 Lankford All analytical methods
Page 373 and 374:
352 should be based upon scientific
Page 375 and 376:
354 Lankford acleaning validation p
Page 377 and 378:
356 In summary, TOC analysis is are
Page 379 and 380:
358 In-Situ In-situ measurement tec
Page 381 and 382:
360 15. Karen A. Clark, Product Man
Page 383 and 384:
362 Actually, most countries revise
Page 385 and 386:
364 §211.100 Written procedures; d
Page 387 and 388:
366 §211.186 Master production and
Page 389 and 390:
368 Equipment Regulation C.02.005 T
Page 391 and 392:
370 … C.02.004 … 4. Pipework sy
Page 393 and 394:
372 5.20 Schedules and procedures (
Page 395 and 396:
374 TABLE 1 Directives of the Europ
Page 397 and 398:
376 TABLE 5 Cleanability Performanc
Page 400 and 401:
Index Accessibility, 28 Acid cleane
Page 402 and 403:
Index 381 CIP supply flow troublesh
Page 404 and 405:
Index 383 [Cleaning cycle sequences
Page 406 and 407:
Index 385 Flow alarm, no-return, 30
Page 408 and 409:
Index 387 Off skid instrumentation,
Page 410 and 411:
Index 389 Rising stem valves, 223-2
Page 412:
Index 391 [Troubleshooting] spray c
show all

Untitled

Create successful ePaper yourself

Delete template?

Save as template?