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Seiberling
FIGURE 14 This single-use eductor-assisted CIP skid has asecond CIP pump and heat exchanger
on the left-hand end as a system capable of supplying flush, wash, and rinse solutions to a
ultrafiltration process skid, from acommon water tank.
& AGood rating for any skid/criteria combination is based on the expectation of
proper engineering design and installation.
Large High-Volume Dual CIP Skid
Whereas this chapter has focused on how arelatively standardorcommon CIP skid
could meet most pharmaceutical and biotech needs, it is recognized that not all CIP
circuits are “standard.”
Figure 15 is a photograph of a CIP skid which included two single-tank
total recycle operation CIP skids upgraded to 200 gal/min (760 L/m) by use of
larger tanks, pumps, and heat exchangers. The two large tanks were installed on
the skid were mounted and piped as surge tanks for the high-quality water
required for the final rinse and available in limited supply, and for CIP waste
neutralization.
CIP Skid with aProcess Function
ACase History of aproject that resulted in aCIP skid being much more, and hence
more affordable, may be of interest to some readers. The original request was for a
CIP skid to clean asmall, but very expensive mixer, which was to be applied to
introduce small quantities of readily soluble drugs into water being recirculated
from amixing tank. Further discussion led to the recognition that the four tanks and
piping also needed to be cleaned.
The CIP skid illustrated in Figure 16 was designed and installed to perform the
functions of drug mixing, CIP of the lines on completion of amixing operation, CIP
of the mixing tanks as they wereemptied, and then CIP of the downstream process at
the end of the production day.The CIP skid was purchased for alesser cost than the