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CIP System Components and Configurations 105 Chemical loop AB FE Chemical loop block PS COND FCV Steam HXR RTD T LS Restrictor COND CIP supply pump (VFD) 0.2 Micron filter CIP recirc tank SG TOV Wash recycle RTD Samp Ret probe Samp CIP return the problem of “balancing” flow produced by CIPS and return pumps. Note that CIPR flow to the CIP recirc tank is by aspray device with areduced discharge tube to direct the major flow to the sidewall, to maximize air disengagement, as discussed previously. The addition of aHWFI tank to the CIP skid will also allow provision of a lower quality water for the pre-rinse, chemical solution washes, and post-chemical solution wash rinses directly to the CIP recirc tank (not shown). This eliminates the need for draining, rinsing, and draining the HWFI tank if alower quality water is used for the initial phases of the CIP program. All other aspects of the operation of this system configuration are asdescribed previously. The rinse to drain illustrated by the heavy line portion of Figure 8starts with the supply of HWFI to the HWFI tank. The water valve admits this water to the CIP pump, the TOV being closed. The rinse is delivered tothe circuit by the CIPS piping and returns through the CIPR piping, passing the return sensors enroute to drain. HBV RTD CIPR recycle LP Water Res probe 0.2 Micron filter HWFI Tank CIP supply HWFI Rupure disc FIGURE 7 The heavy lines on this diagram depict wash recycle flow through aconventional twotank clean-in-place skid.
106 Chemical loop AB FE Chemical block loop PS COND FCV Steam HXR RTD T LS Restrictor COND CIP supply pump (VFD) 0.2 Micron filter CIP recirc tank SG TOV Rinse to drain RTD Samp Ret probe Samp CIP return Multi-Tank CIP Configuration with CIP RECIRC TANK after CIPR to Drain This alternative to Figures 7and 8provides mix-proof valve separation of the CIP recirc tank and HWFI tank, assuring no possibility of either alower grade water from the CIP recirc tank, or wash solution and soil contacting any part of the HWFI tank and supply piping. And, placing the CIP recirc tank on the end of the circuit assures that it is fully subjected to all of the time, concentration, and temperature criteria applied to cleaning the process circuit. This second multi-tank CIP skid illustrated in Figures 9and 10 is similar to the above but differs in two respects. Astandardshutoffvalve controls flow through the top port of amix-proof valve (not through the valve passage) for flow from the CIP recirc tank to drain. The mix-proof valves on the HWFI tank and CIPR recycle tank outlet lines connect the vessels to the CIP pump with the equivalent of “doubleblock-and-bleed” separation of the two streams. The wash recycle circuit is illustrated in Figure 9and the rinse to drain in Figure 10. The two systems are comparable with respect to program control equipment including instrument sensors and I/O, and the multi-tank CIP skids also HBV RTD CIPR recycle LP Water 0.2 Micron filter Res probe HWFI tank CIP supply HWFI Seiberling Rupure disc FIGURE 8 The heavy lines on this diagram depict the rinse to drain flow through aconventional two-tank clean-in-place skid.
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Clean-In-Place for Biopharmaceutica
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Informa Healthcare USA, Inc. 52 Van
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iv Preface period, the industry rec
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Preface iii Contents Acknowledgment
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Contributors Barry J. Andersen Seib
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2 the last step of abatch manufactu
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4 Seiberling The vessel capacity ma
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6 Seiberling any two ports. For pur
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8 AWFI (or Any Water) Supply If the
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10 Seiberling program, and through
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12 Seiberling (380 L) for the solut
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14 AWFI CIP skid Drain When steam a
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16 Seiberling products in asingle f
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18 Seiberling The literature began
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2 Project Planning for the CIPable
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Project Planning for CIPable Facili
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3 Water for the CIP System Jay C. A
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Water for the CIP System 43 FIGURE
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Water for the CIP System 45 of clea
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Water for the CIP System 51 WATER U
Page 75 and 76: 54 Time Temperature FIGURE 2 The cl
Page 77 and 78: 56 Classification of Cleaners by pH
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Page 81 and 82: 60 + - Na O O C CH 2 CH 2 (CH 2 ) n
Page 83 and 84: 62 CH3 -(CH2 ) n -CH2 -O -CH2 -CH2
Page 85 and 86: 64 B C D E FIGURE 17 Capability of
Page 87 and 88: 66 pH 13 pH 7 pH, %, Excess water h
Page 89 and 90: 68 dramatically increased rinsing t
Page 91 and 92: 70 desorption. If the affinity is v
Page 93 and 94: 72 & Cleaning procedure inthe case
Page 95 and 96: 74 effort being performed relativel
Page 97 and 98: 76 Rush & A1000 Lmixing vessel, hav
Page 99 and 100: 78 TABLE 2 Typical Single-Pass Chem
Page 101 and 102: 80 Rush Rinse Volume (Duration) The
Page 103 and 104: 82 Rush Intermediate Drain Objectiv
Page 105 and 106: 84 Rush Final Drain Phase (Gravity)
Page 107 and 108: 86 TABLE 4 Recirculated Chemical Wa
Page 109 and 110: 88 Rush type of soil include fermen
Page 111 and 112: 90 The pre-cleaning process flush w
Page 113 and 114: 92 REFERENCES Rush 1. Howard T, Wie
Page 115 and 116: 94 CIP return (CIPR)-piping to conv
Page 117 and 118: 96 Seiberling provided, generally o
Page 119 and 120: 98 Single-Tank CIP Skid Operational
Page 121 and 122: 100 Single-Tank Bypass or Recycle O
Page 123 and 124: 102 Seiberling Single-Tank Single P
Page 125: 104 Seiberling installation of an e
Page 129 and 130: 108 Chemical loop AB FCV FE Steam C
Page 131 and 132: CIP supply Transfer line (typical)
Page 133 and 134: 112 Seiberling FIGURE 14 This singl
Page 135 and 136: 114 Seiberling FIGURE 15 This large
Page 137 and 138: 116 Seiberling FIGURE 17 This mini-
Page 140 and 141: 7 CIP System Instrumentation and Co
Page 142 and 143: CIP System Instrumentation and Cont
Page 164: CIP System Instrumentation and Cont
Page 167 and 168: 146 Lebowitz should be considered f
Page 169 and 170: 148 Lebowitz barrels and the chemic
Page 171 and 172: 150 Lebowitz Electromagnetic-Operat
Page 173 and 174: 152 Lebowitz FIGURE 5 The venturi o
Page 175 and 176: 154 Chemical pump enclosure Acid AL
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156 Steam Facility acid header Faci
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158 Lebowitz That is to say aweak a
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160 CIP Philosophy The production p
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162 Franks and Seiberling the numbe
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164 Franks and Seiberling Similar s
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166 Franks and Seiberling FIGURE 3
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170 (A) (B) Franks and Seiberling F
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174 The variables that impact the r
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176 There are two guiding concepts
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178 Mezz. Floor(ref.) V-5 1000L CIP
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180 return line piping, substantial
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182 Lebowitz U-bend transfer panels
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184 Lebowitz oriented vertically. T
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186 Lebowitz suction-side port on T
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CIPS loop Primary CIPS CIPSPS CIPS
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190 Lebowitz FIGURE 10 Photo of sma
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192 Drain CIP return Drain Recycle
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11 Materials of Construction and Su
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Materials of Construction and Surfa
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12 Cleanable In-Line Components INT
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Cleanable In-Line Components 213 &
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Cleanable In-Line Components 215 Al
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Cleanable In-Line Components 217 Ex
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Cleanable In-Line Components 219 FI
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Cleanable In-Line Components 221 Tr
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Cleanable In-Line Components 223 it
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Cleanable In-Line Components 229 eq
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Cleanable In-Line Components 231 Th
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Cleanable In-Line Components 233 co
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13 Cleanable Liquids Processing Equ
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Cleanable Liquids Processing Equipm
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1-9 CIPS 2 Plant steam CIPS valves
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258 8. Projectile-type thermometer
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260 Forder control of the drying pr
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262 Forder FIGURE 5 Pharmaceutical
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264 Forder FIGURE 7 Pharmaceutical
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266 FIGURE 9 Pleated filter cartrid
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268 FIGURE 12 Disassembledstainless
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270 The acid wash of 85% phosphoric
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272 FIGURE 17 Sanitary Vbenders. So
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274 one each for the upper, central
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276 CIP VS. TRADITIONAL BOIL-UP MET
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278 Cerulli were not designed to be
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280 by large flanged connections fo
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282 CIP header Once thru CIP soluti
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284 Nozzle Use A Manway B Agitator
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286 3" Stub end w/150# flange 2A 1
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288 In most cases, the pressure dro
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290 CIP fluids Process fluids 1 2 3
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292 A Vent to atm. B M Conical drye
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294 One of the designer’s first t
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16 CIP System Troubleshooting Guide
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CIP System Troubleshooting Guide 29
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17 Waste Treatment for the CIP Syst
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Waste Treatment for the CIP System
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18 Commissioning and Qualification
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Commissioning and Qualification 329
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348 & Sterilization refers to the r
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350 Lankford All analytical methods
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352 should be based upon scientific
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354 Lankford acleaning validation p
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356 In summary, TOC analysis is are
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358 In-Situ In-situ measurement tec
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360 15. Karen A. Clark, Product Man
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362 Actually, most countries revise
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364 §211.100 Written procedures; d
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366 §211.186 Master production and
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368 Equipment Regulation C.02.005 T
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370 … C.02.004 … 4. Pipework sy
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372 5.20 Schedules and procedures (
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374 TABLE 1 Directives of the Europ
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376 TABLE 5 Cleanability Performanc
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Index Accessibility, 28 Acid cleane
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Index 381 CIP supply flow troublesh
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Index 383 [Cleaning cycle sequences
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Index 385 Flow alarm, no-return, 30
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Index 387 Off skid instrumentation,
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Index 389 Rising stem valves, 223-2
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Index 391 [Troubleshooting] spray c
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