Physiologic and Supraphysiologic Increases in Lipoprotein Lipids ...

PREGNANCY HYPERLIPIDEMIA AND PRELIPEMIA Montes et al. 411
Table 3. LIpoprotein Lipid and Apoproteln Ratios In 23 Women in Late Pregnancy and Postpartum and In 23
Age- and Body-Mass-Matched Nonpregnant Controls
VLDL
TG/chol
TG/apo B
Chol/apo B
LDL
TG/chol
TG/apo B
Chol/apo B
HDL
TG/chol
TG/apo A-1
Chol/apo A-1
Pregnant
Weeks 34-38
Mean±SD Median Mean
5.10±1.10 5.00*
7.79 ±5.07 5.21
1.57 ±0.98 0.99
0.46±0.10
0.91 ±0.30
2.02 + 0.65
0.44*
0.87*
1.93
0.46 ±0.15 0.50*
0.18±0.05 0.16*
0.39 ±0.07 0.40*
Week 6 Week 20
±SD
4.88 ±2.40 4.00*
9.30±9.08 7.00
2.31+3.07 1.60
0.23 ±0.08
0.26 + 0.08
1.21 ±0.25
0.14±0.06
0.07 ±0.03
0.51 ±0.11
Postpartum
Median Mean±sD
0.22*t
0.25f
1.14*t
0.13*t
0.07t
0.48*t
'Significantly different from controls at p s 0.05.
tSignificantly different from antepartum at p == 0.05.
^Significantly different from 6 weeks postpartum at p ^ 0.05.
80-
60-
I6O-
80-
mg/dl
240-
I6O
80-
O- 1
Glucose
Triglycerkje
Cholesterol
8 16 24
Pregnancy
6.14±3.76
7.56 ±4.01
1.50 ±1.02
0.20 ±0.07
0.26 ±0.08
1.38 ±0.29
0.15 ±0.08
0.07 + 0.03
0.42 ±0.08
32 40
Weeks
Median
5.67*
6.18
1.15
0.20*t
0.25f
1.43*t
0.16*t
0.07*t
-VLDL
Nonpregnant controls
Mean±sD
3.69 ±3.48
10.88± 14.86
3.06 ±3.32
0.14 + 0.08
0.23±0.17
1.72 ±0.28
0.21 ±0.09
0.09 ±0.04
0.44 + 0.06
LDL
6 20
Posfpartum
Figure 2. Plasma glucose, triglyceride, and cholesterol and lipoprotein cholesterol
concentrations in subject EW before, during, and after pregnancy. Glucose declined
while all lipids increased throughout pregnancy. Postpartum, triglyceride and VLDL
cholesterol fell to slightly below prepregnancy levels by 6 weeks of gestation and HDL
cholesterol fell to normal by 20 weeks. LDL cholesterol declined more slowly and
remained above prepregnancy levels at 20 weeks postpartum.
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Median
2.99
4.11
1.50
0.12
0.22
1.74
0.20
0.09
0.44