Acino adds blockbuster esomeprazole to its product portfolio

Acino adds blockbuster esomeprazole to its product portfolio Acino adds blockbuster esomeprazole to its product portfolio

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NEWS RELEASE — PRESSEMITTEILUNG Acino adds blockbuster esomeprazole to its product portfolio Basle, April 2, 2012, 07.00 hrs — Shortly after having acquired Cephalon/Mepha’s international business in the Middle East, Africa, Asia and Latin America, Acino continues its expansion in global emerging markets under its «Acino Switzerland» brand by successfully in-licensing the blockbuster drug esomeprazole. The licensing agreements include esomeprazole 20 mg and 40 mg MUPS (Multiple Unit Particulate Systems) tablets, and esomeprazole 40 mg lyophilized powder for injection. The esomeprazole MUPS tablets are being produced at Acino’s manufacturing site in Liesberg (Canton Baselland, Switzerland). Esomeprazole (original product Nexium® from AstraZeneca), a proton pump inhibitor (PPI), is being used in the treatment of indications such as dyspepsia, peptic ulcer disease (PUD), gastro-esophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. The product (oral and parenteral presentations) generated worldwide annual sales of over USD 8.7 billion (MAT 06/2011) and is among the top five drugs in several of Acino’s target markets. Through this in-licensing agreement Acino will further strengthen its position in the gastrointestinal therapeutic area. The company is anticipating a good match with its strong franchise with the branded product Gasec® (omeprazole), which Mepha built up over the years in different international markets. In addition, Acino successfully completed the inlicensing of another PPI, pantoprazole 40 mg, for injection. Dr. Manuel Heim, Head of Global Marketing, said: “We consider this an excellent fit to support our own-brand marketing strategy of providing Swiss quality products with advanced and refined application technologies such as MUPS, ensuring effective relief to patients. We expect to add more products to our existing portfolio with a focus on the therapeutic areas pain, oncology, urology, antiinfectives, cardiovascular disease, gastrointestinal disorders, and others. Ruud van Anraat, Chief Commercial Officer, added: “ Acino - with its Swiss base, international market presence, and high quality standards - will be ideally placed to capitalize on the potential of these products in up and coming markets. It underscores our dedication and focus, making «Acino Switzerland» a preferred partner in emerging markets with the aim to make quality medicine accessible for the benefit of the patient.” Acino Holding Ltd. Erlenstrasse 1 CH-4058 Basle Phone +41 61 338 60 00 Fax +41 61 338 60 80 www.acino-pharma.com

NEWS RELEASE — PRESSEMITTEILUNG<br />

<strong>Acino</strong> <strong>adds</strong> <strong>blockbuster</strong> <strong>esomeprazole</strong> <strong>to</strong> <strong>its</strong> <strong>product</strong><br />

<strong>portfolio</strong><br />

Basle, April 2, 2012, 07.00 hrs — Shortly after having acquired Cephalon/Mepha’s international<br />

business in the Middle East, Africa, Asia and Latin America, <strong>Acino</strong> continues<br />

<strong>its</strong> expansion in global emerging markets under <strong>its</strong> «<strong>Acino</strong> Switzerland» brand by successfully<br />

in-licensing the <strong>blockbuster</strong> drug <strong>esomeprazole</strong>. The licensing agreements include<br />

<strong>esomeprazole</strong> 20 mg and 40 mg MUPS (Multiple Unit Particulate Systems) tablets,<br />

and <strong>esomeprazole</strong> 40 mg lyophilized powder for injection. The <strong>esomeprazole</strong> MUPS tablets<br />

are being produced at <strong>Acino</strong>’s manufacturing site in Liesberg (Can<strong>to</strong>n Baselland,<br />

Switzerland).<br />

Esomeprazole (original <strong>product</strong> Nexium® from AstraZeneca), a pro<strong>to</strong>n pump inhibi<strong>to</strong>r<br />

(PPI), is being used in the treatment of indications such as dyspepsia, peptic ulcer disease<br />

(PUD), gastro-esophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome.<br />

The <strong>product</strong> (oral and parenteral presentations) generated worldwide annual<br />

sales of over USD 8.7 billion (MAT 06/2011) and is among the <strong>to</strong>p five drugs in several of<br />

<strong>Acino</strong>’s target markets.<br />

Through this in-licensing agreement <strong>Acino</strong> will further strengthen <strong>its</strong> position in the gastrointestinal<br />

therapeutic area. The company is anticipating a good match with <strong>its</strong> strong franchise<br />

with the branded <strong>product</strong> Gasec® (omeprazole), which Mepha built up over the<br />

years in different international markets. In addition, <strong>Acino</strong> successfully completed the inlicensing<br />

of another PPI, pan<strong>to</strong>prazole 40 mg, for injection.<br />

Dr. Manuel Heim, Head of Global Marketing, said: “We consider this an excellent fit <strong>to</strong><br />

support our own-brand marketing strategy of providing Swiss quality <strong>product</strong>s with advanced<br />

and refined application technologies such as MUPS, ensuring effective relief <strong>to</strong><br />

patients. We expect <strong>to</strong> add more <strong>product</strong>s <strong>to</strong> our existing <strong>portfolio</strong> with a focus on the<br />

therapeutic areas pain, oncology, urology, antiinfectives, cardiovascular disease, gastrointestinal<br />

disorders, and others.<br />

Ruud van Anraat, Chief Commercial Officer, added: “ <strong>Acino</strong> - with <strong>its</strong> Swiss base, international<br />

market presence, and high quality standards - will be ideally placed <strong>to</strong> capitalize on<br />

the potential of these <strong>product</strong>s in up and coming markets. It underscores our dedication<br />

and focus, making «<strong>Acino</strong> Switzerland» a preferred partner in emerging markets with the<br />

aim <strong>to</strong> make quality medicine accessible for the benefit of the patient.”<br />

<strong>Acino</strong> Holding Ltd.<br />

Erlenstrasse 1<br />

CH-4058 Basle<br />

Phone +41 61 338 60 00<br />

Fax +41 61 338 60 80<br />

www.acino-pharma.com


<strong>Acino</strong> – Delivering Health<br />

<strong>Acino</strong> (SIX: ACIN), a Swiss-based pharmaceutical company, develops, manufactures and internationally<br />

markets well-proven and innovative pharmaceuticals in novel drug delivery forms. <strong>Acino</strong> is a<br />

leader in advanced drug delivery technologies with a focus on modified release oral forms, oral<br />

dispersible forms, transdermal systems and extended release parenterals, for which it also holds<br />

patents. As a partner of pharmaceutical companies worldwide, <strong>Acino</strong> supplies finished in-house<br />

developed <strong>product</strong>s and/or provides cus<strong>to</strong>mized one-s<strong>to</strong>p solutions from <strong>product</strong> development and<br />

registration <strong>to</strong> contract manufacturing, packaging and logistics. Under the brand “<strong>Acino</strong> Switzerland”,<br />

<strong>Acino</strong> markets Swiss-quality medicines in up and coming economies. The <strong>Acino</strong> Group is<br />

headquartered in Basle, at present has about 870 employees (including staff members from<br />

Mepha) and generated annual revenues of EUR 135 million in 2011.<br />

Contact Calendar<br />

Peter Burema<br />

CEO <strong>Acino</strong> Group<br />

Phone +41 61 338 60 00<br />

info@acino-pharma.com<br />

www.acino-pharma.com<br />

Page 2 / 22<br />

5.4.2012 General Meeting of Shareholders<br />

11.4.2012 Dividend ex-date<br />

13.4.2012 Dividend record date<br />

16.4.2012 Dividend payment date<br />

2.8.2012 Half-year report as of June 30, 2012<br />

<strong>Acino</strong> Holding Ltd.<br />

Erlenstrasse 1<br />

CH-4058 Basle<br />

Phone +41 61 338 60 00<br />

Fax +41 61 338 60 80<br />

www.acino-pharma.com

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