Voie d'immunisation et séquence d'administration de l ... - TEL

tel-00827710, version 1 - 29 May 2013
Table 4. Mouse DC subsets. Mono-DC, Monocyte-derived DC; LC, Langherans cell. (*) This subset
was shown to respond to poly I:C but TLR3 was not identified in these cells.
2) Specialization
(a) Ability to present antigen
The different cDC subsets have been described to have various abilities for antigen uptake
and presentation. The CD8α + DCs showed a superior capacity to take up dying cells (Iyoda et
al., 2002), which is correlated with their relatively increased expression of some receptors
known for clearance of dead cells, such as Clec9A. Moreover this subset has been
demonstrated to better cross-present antigen compared to the CD8α - DC subset from the
Page 37 of 256