Voie d'immunisation et séquence d'administration de l ... - TEL

tel-00827710, version 1 - 29 May 2013
Table 1. Diversity of Toll-like receptors. dsRNA, double-stranded RNA, ssRNA, single-stranded
RNA.
(i) Toll-Like Receptors
TLRs are transmembrane receptors that can be found in various cellular compartments (Table
1). This family of receptors can be divided into two groups based on expression location and
ligand specificity. TLR1, 2, 4, 5, 6 and 11 are expressed on the cell surface and recognize
mainly microbial membrane components such as lipids, lipoproteins and proteins. TLR3, 7, 8
and 9 recognize nucleic acids and are localized in intracellular compartments such as
endosomes and lysosomes. Studies of mice deficient for the different TLRs have
Page 31 of 256