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tel-00827710, version 1 - 29 May 2013 Sancho, D., Joffre, O.P., Keller, A.M., Rogers, N.C., Martinez, D., Hernanz-Falcon, P., Rosewell, I., and Reis e Sousa, C. (2009). Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458, 899-903. Santini, S.M., Lapenta, C., Logozzi, M., Parlato, S., Spada, M., Di Pucchio, T., and Belardelli, F. (2000). Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 191, 1777- 1788. Savina, A., and Amigorena, S. (2007). Phagocytosis and antigen presentation in dendritic cells. Immunol Rev 219, 143-156. Savina, A., Jancic, C., Hugues, S., Guermonprez, P., Vargas, P., Moura, I.C., Lennon- Dumenil, A.M., Seabra, M.C., Raposo, G., and Amigorena, S. (2006). NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126, 205-218. Schepers, K., Swart, E., van Heijst, J.W., Gerlach, C., Castrucci, M., Sie, D., Heimerikx, M., Velds, A., Kerkhoven, R.M., Arens, R., et al. (2008). Dissecting T cell lineage relationships by cellular barcoding. J Exp Med 205, 2309-2318. Schilte, C., Couderc, T., Chretien, F., Sourisseau, M., Gangneux, N., Guivel-Benhassine, F., Kraxner, A., Tschopp, J., Higgs, S., Michault, A., et al. (2010). Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med 207, 429-442. Schlom, J., Arlen, P.M., and Gulley, J.L. (2007). Cancer vaccines: moving beyond current paradigms. Clin Cancer Res 13, 3776-3782. Schmidt, C. (2007). Clinical setbacks for toll-like receptor 9 agonists in cancer. Nat Biotechnol 25, 825-826. Schmidt, C.S., and Mescher, M.F. (1999). Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo. J Immunol 163, 2561-2567. Schmidt, J., Neumann-Haefelin, C., Altay, T., Gostick, E., Price, D.A., Lohmann, V., Blum, H.E., and Thimme, R. (2011). Immunodominance of HLA-A2-restricted hepatitis C virusspecific CD8+ T cell responses is linked to naive-precursor frequency. J Virol 85, 5232-5236. Schroder, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832. Schulz, O., Diebold, S.S., Chen, M., Naslund, T.I., Nolte, M.A., Alexopoulou, L., Azuma, Y.T., Flavell, R.A., Liljestrom, P., and Reis e Sousa, C. (2005). Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433, 887-892. Schulze, D.H., Pease, L.R., Geier, S.S., Reyes, A.A., Sarmiento, L.A., Wallace, R.B., and Nathenson, S.G. (1983). Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A 80, 2007- 2011. Schumacher, T.N., Gerlach, C., and van Heijst, J.W. (2010). Mapping the life histories of T cells. Nat Rev Immunol 10, 621-631. Schwarz, K., Storni, T., Manolova, V., Didierlaurent, A., Sirard, J.C., Rothlisberger, P., and Bachmann, M.F. (2003). Role of Toll-like receptors in costimulating cytotoxic T cell responses. Eur J Immunol 33, 1465-1470. Seder, R.A., Darrah, P.A., and Roederer, M. (2008). T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8, 247-258. 250

tel-00827710, version 1 - 29 May 2013 Semmling, V., Lukacs-Kornek, V., Thaiss, C.A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D.I., et al. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11, 313-320. Shiow, L.R., Rosen, D.B., Brdickova, N., Xu, Y., An, J., Lanier, L.L., Cyster, J.G., and Matloubian, M. (2006). CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440, 540-544. Shirai, M., Pendleton, C.D., Ahlers, J., Takeshita, T., Newman, M., and Berzofsky, J.A. (1994). Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. J Immunol 152, 549-556. Shirota, H., and Klinman, D.M. (2011). CpG-conjugated apoptotic tumor cells elicit potent tumor-specific immunity. Cancer Immunol Immunother 60, 659-669. Sondak, V.K., and Sosman, J.A. (2003). Results of clinical trials with an allogenic melanoma tumor cell lysate vaccine: Melacine. Semin Cancer Biol 13, 409-415. Spadaro, F., Lapenta, C., Donati, S., Abalsamo, L., Barnaba, V., Belardelli, F., Santini, S.M., and Ferrantini, M. (2012). IFN-alpha enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing. Blood 119, 1407-1417. Sporri, R., and Reis e Sousa, C. (2005). Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 6, 163-170. Steinman, R.M. (2003). Some interfaces of dendritic cell biology. APMIS 111, 675-697. Steinman, R.M., and Nussenzweig, M.C. (2002). Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 99, 351-358. Stemberger, C., Huster, K.M., Koffler, M., Anderl, F., Schiemann, M., Wagner, H., and Busch, D.H. (2007). A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity 27, 985-997. Storni, T., Ruedl, C., Renner, W.A., and Bachmann, M.F. (2003). Innate immunity together with duration of antigen persistence regulate effector T cell induction. J Immunol 171, 795- 801. Strasser, A. (2005). The role of BH3-only proteins in the immune system. Nat Rev Immunol 5, 189-200. Sung, S.S., Fu, S.M., Rose, C.E., Jr., Gaskin, F., Ju, S.T., and Beaty, S.R. (2006). A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol 176, 2161-2172. Takemoto, N., Intlekofer, A.M., Northrup, J.T., Wherry, E.J., and Reiner, S.L. (2006). Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol 177, 7515-7519. Takeuchi, O., and Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820. Thompson, L.J., Kolumam, G.A., Thomas, S., and Murali-Krishna, K. (2006). Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation. J Immunol 177, 1746-1754. Page 251 of 256

tel-00827710, version 1 - 29 May 2013<br />

Sancho, D., Joffre, O.P., Keller, A.M., Rogers, N.C., Martinez, D., Hernanz-Falcon, P.,<br />

Rosewell, I., and Reis e Sousa, C. (2009). I<strong>de</strong>ntification of a <strong>de</strong>ndritic cell receptor that<br />

couples sensing of necrosis to immunity. Nature 458, 899-903.<br />

Santini, S.M., Lapenta, C., Logozzi, M., Parlato, S., Spada, M., Di Pucchio, T., and<br />

Belar<strong>de</strong>lli, F. (2000). Type I interferon as a powerful adjuvant for monocyte-<strong>de</strong>rived <strong>de</strong>ndritic<br />

cell <strong>de</strong>velopment and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 191, 1777-<br />

1788.<br />

Savina, A., and Amigorena, S. (2007). Phagocytosis and antigen presentation in <strong>de</strong>ndritic<br />

cells. Immunol Rev 219, 143-156.<br />

Savina, A., Jancic, C., Hugues, S., Guermonprez, P., Vargas, P., Moura, I.C., Lennon-<br />

Dumenil, A.M., Seabra, M.C., Raposo, G., and Amigorena, S. (2006). NOX2 controls<br />

phagosomal pH to regulate antigen processing during crosspresentation by <strong>de</strong>ndritic cells.<br />

Cell 126, 205-218.<br />

Schepers, K., Swart, E., van Heijst, J.W., Gerlach, C., Castrucci, M., Sie, D., Heimerikx, M.,<br />

Velds, A., Kerkhoven, R.M., Arens, R., <strong>et</strong> al. (2008). Dissecting T cell lineage relationships<br />

by cellular barcoding. J Exp Med 205, 2309-2318.<br />

Schilte, C., Cou<strong>de</strong>rc, T., Chr<strong>et</strong>ien, F., Sourisseau, M., Gangneux, N., Guivel-Benhassine, F.,<br />

Kraxner, A., Tschopp, J., Higgs, S., Michault, A., <strong>et</strong> al. (2010). Type I IFN controls<br />

chikungunya virus via its action on nonhematopoi<strong>et</strong>ic cells. J Exp Med 207, 429-442.<br />

Schlom, J., Arlen, P.M., and Gulley, J.L. (2007). Cancer vaccines: moving beyond current<br />

paradigms. Clin Cancer Res 13, 3776-3782.<br />

Schmidt, C. (2007). Clinical s<strong>et</strong>backs for toll-like receptor 9 agonists in cancer. Nat<br />

Biotechnol 25, 825-826.<br />

Schmidt, C.S., and Mescher, M.F. (1999). Adjuvant effect of IL-12: conversion of pepti<strong>de</strong><br />

antigen administration from tolerizing to immunizing for CD8+ T cells in vivo. J Immunol<br />

163, 2561-2567.<br />

Schmidt, J., Neumann-Haefelin, C., Altay, T., Gostick, E., Price, D.A., Lohmann, V., Blum,<br />

H.E., and Thimme, R. (2011). Immunodominance of HLA-A2-restricted hepatitis C virusspecific<br />

CD8+ T cell responses is linked to naive-precursor frequency. J Virol 85, 5232-5236.<br />

Schro<strong>de</strong>r, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832.<br />

Schulz, O., Diebold, S.S., Chen, M., Naslund, T.I., Nolte, M.A., Alexopoulou, L., Azuma,<br />

Y.T., Flavell, R.A., Liljestrom, P., and Reis e Sousa, C. (2005). Toll-like receptor 3 promotes<br />

cross-priming to virus-infected cells. Nature 433, 887-892.<br />

Schulze, D.H., Pease, L.R., Geier, S.S., Reyes, A.A., Sarmiento, L.A., Wallace, R.B., and<br />

Nathenson, S.G. (1983). Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb<br />

gene shows a cluster of seven nucleoti<strong>de</strong> differences. Proc Natl Acad Sci U S A 80, 2007-<br />

2011.<br />

Schumacher, T.N., Gerlach, C., and van Heijst, J.W. (2010). Mapping the life histories of T<br />

cells. Nat Rev Immunol 10, 621-631.<br />

Schwarz, K., Storni, T., Manolova, V., Didierlaurent, A., Sirard, J.C., Rothlisberger, P., and<br />

Bachmann, M.F. (2003). Role of Toll-like receptors in costimulating cytotoxic T cell<br />

responses. Eur J Immunol 33, 1465-1470.<br />

Se<strong>de</strong>r, R.A., Darrah, P.A., and Roe<strong>de</strong>rer, M. (2008). T-cell quality in memory and protection:<br />

implications for vaccine <strong>de</strong>sign. Nat Rev Immunol 8, 247-258.<br />

250

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