tel-00827710, version 1 - 29 May 2013 Dubsky, P., Saito, H., Leogier, M., Dantin, C., Connolly, J.E., Banchereau, J., and Palucka, A.K. (2007). IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL. Eur J Immunol 37, 1678-1690. Dudziak, D., Kamphorst, A.O., Heidkamp, G.F., Buchholz, V.R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.W., Park, C.G., <strong>et</strong> al. (2007). Differential antigen processing by <strong>de</strong>ndritic cell subs<strong>et</strong>s in vivo. Science 315, 107-111. Durand, V., Wong, S.Y., Tough, D.F., and Le Bon, A. (2004). Shaping of adaptive immune responses to soluble proteins by TLR agonists: a role for IFN-alpha/b<strong>et</strong>a. Immunol Cell Biol 82, 596-602. Edwards, A.D., Diebold, S.S., Slack, E.M., Tomizawa, H., Hemmi, H., Kaisho, T., Akira, S., and Reis e Sousa, C. (2003). Toll-like receptor expression in murine DC subs<strong>et</strong>s: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 33, 827-833. Farsaci, B., Higgins, J.P., and Hodge, J.W. (2012). Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy. Int J Cancer 130, 1948-1959. Fayolle, C., Deriaud, E., and Leclerc, C. (1991). In vivo induction of cytotoxic T cell response by a free synth<strong>et</strong>ic pepti<strong>de</strong> requires CD4+ T cell help. J Immunol 147, 4069-4073. Fesik, S.W. (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5, 876-885. Filatenkov, A.A., Jacov<strong>et</strong>ty, E.L., Fischer, U.B., Curtsinger, J.M., Mescher, M.F., and Ingulli, E. (2005). CD4 T cell-<strong>de</strong>pen<strong>de</strong>nt conditioning of <strong>de</strong>ndritic cells to produce IL-12 results in CD8-mediated graft rejection and avoidance of tolerance. J Immunol 174, 6909-6917. Fontana, R., Bregni, M., Cipponi, A., Raccosta, L., Rainelli, C., Maggioni, D., Lunghi, F., Ciceri, F., Mukenge, S., Doglioni, C., <strong>et</strong> al. (2009). Peripheral blood lymphocytes gen<strong>et</strong>ically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients. Blood 113, 1651-1660. Fotin-Mleczek, M., Duchardt, K.M., Lorenz, C., Pfeiffer, R., Ojkic-Zrna, S., Probst, J., and Kallen, K.J. (2011). Messenger RNA-based vaccines with dual activity induce balanced TLR- 7 <strong>de</strong>pen<strong>de</strong>nt adaptive immune responses and provi<strong>de</strong> antitumor activity. J Immunother 34, 1- 15. Francois-Newton, V., Magno <strong>de</strong> Freitas Almeida, G., Payelle-Brogard, B., Monneron, D., Pichard-Garcia, L., Piehler, J., Pellegrini, S., and Uze, G. (2011). USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon alpha response. PLoS One 6, e22200. Frebel, H., Richter, K., and Oxenius, A. (2010). How chronic viral infections impact on antigen-specific T-cell responses. Eur J Immunol 40, 654-663. Freeman, G.J., Casasnovas, J.M., Um<strong>et</strong>su, D.T., and DeKruyff, R.H. (2010). TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235, 172-189. Fuertes Marraco, S.A., Scott, C.L., Bouill<strong>et</strong>, P., Ives, A., Masina, S., Vremec, D., Jansen, E.S., O'Reilly, L.A., Schnei<strong>de</strong>r, P., Fasel, N., <strong>et</strong> al. (2011). Type I interferon drives <strong>de</strong>ndritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo. PLoS One 6, e20189. 242
tel-00827710, version 1 - 29 May 2013 Fuertes, M.B., Kacha, A.K., Kline, J., Woo, S.R., Kranz, D.M., Murphy, K.M., and Gajewski, T.F. (2011). Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ <strong>de</strong>ndritic cells. J Exp Med 208, 2005-2016. Fujii, S., Liu, K., Smith, C., Bonito, A.J., and Steinman, R.M. (2004). The linkage of innate to adaptive immunity via maturing <strong>de</strong>ndritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 199, 1607-1618. Gallucci, S., Lolkema, M., and Matzinger, P. (1999). Natural adjuvants: endogenous activators of <strong>de</strong>ndritic cells. Nat Med 5, 1249-1255. Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E.E., Trinchieri, G., Caux, C., and Garrone, P. (2005). A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secr<strong>et</strong>ion by <strong>de</strong>ndritic cells. J Exp Med 201, 1435-1446. Gea-Banacloche, J.C., Migueles, S.A., Martino, L., Shupert, W.L., McNeil, A.C., Sabbaghian, M.S., Ehler, L., Prussin, C., Stevens, R., Lambert, L., <strong>et</strong> al. (2000). Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J Immunol 165, 1082-1092. Gerlach, C., van Heijst, J.W., Swart, E., Sie, D., Armstrong, N., Kerkhoven, R.M., Zehn, D., Bevan, M.J., Schepers, K., and Schumacher, T.N. (2010). One naive T cell, multiple fates in CD8+ T cell differentiation. J Exp Med 207, 1235-1246. Ginhoux, F., Collin, M.P., Bogunovic, M., Abel, M., Leboeuf, M., Helft, J., Ochando, J., Kissenpfennig, A., Malissen, B., Grisotto, M., <strong>et</strong> al. (2007). Blood-<strong>de</strong>rived <strong>de</strong>rmal langerin+ <strong>de</strong>ndritic cells survey the skin in the steady state. J Exp Med 204, 3133-3146. Gogas, H., Ioannovich, J., Dafni, U., Stavropoulou-Giokas, C., Frangia, K., Tsoutsos, D., Panagiotou, P., Polyzos, A., Papadopoulos, O., Stratigos, A., <strong>et</strong> al. (2006). Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 354, 709-718. Gottschalk, R.A., Hathorn, M.M., Beuneu, H., Corse, E., Dustin, M.L., Altan-Bonn<strong>et</strong>, G., and Allison, J.P. (2012). Distinct influences of pepti<strong>de</strong>-MHC quality and quantity on in vivo Tcell responses. Proc Natl Acad Sci U S A. Green, D.R. (2011). The end and after: how dying cells impact the living organism. Immunity 35, 441-444. Guermonprez, P., Saveanu, L., Kleijmeer, M., Davoust, J., Van En<strong>de</strong>rt, P., and Amigorena, S. (2003). ER-phagosome fusion <strong>de</strong>fines an MHC class I cross-presentation compartment in <strong>de</strong>ndritic cells. Nature 425, 397-402. Hadrup, S.R., Bakker, A.H., Shu, C.J., An<strong>de</strong>rsen, R.S., van Veluw, J., Hombrink, P., Castermans, E., Thor Straten, P., Blank, C., Haanen, J.B., <strong>et</strong> al. (2009). Parallel d<strong>et</strong>ection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. Nat M<strong>et</strong>hods 6, 520-526. Hasan, U.A., Caux, C., Perrot, I., Doffin, A.C., Men<strong>et</strong>rier-Caux, C., Trinchieri, G., Tommasino, M., and Vlach, J. (2007). Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. Proc Natl Acad Sci U S A 104, 8047-8052. He, S., Liang, Y., Shao, F., and Wang, X. (2011). Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A 108, 20054-20059. Heath, W.R., Belz, G.T., Behrens, G.M., Smith, C.M., Forehan, S.P., Parish, I.A., Davey, G.M., Wilson, N.S., Carbone, F.R., and Villadangos, J.A. (2004). Cross-presentation, Page 243 of 256
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