Voie d'immunisation et séquence d'administration de l ... - TEL

tel-00827710, version 1 - 29 May 2013
Table 6. Combination of antigen with adjuvant. Compiled from our data and previous studies, we
predict the optimal timing for adjuvant delivery.
5) Conclusion
Together, these results highlight the need for an increased and deeper understanding of the
mechanisms of antigen uptake, processing and presentation in order to adapt the timing for
optimal adjuvant delivery. Each form of antigen likely requires a different adjuvant delivery
schedule. Cell-associated antigen requires the longest time between immunization and
presentation, and therefore a delay should be considered when deciding upon an adjuvant
delivery schedule. Although the presentation requires the same processing as cell-associated
antigen, vaccination with a soluble protein antigen that disseminates quickly will result in a
more rapide presentation and reduce the overall duration of the process. Consequently, the
optimal timing for adjuvant administration will be closer to the initial timing of
immunization. Finally, vaccination with a peptide, that directly interacts with the MHC
molecules triggers a rapid presentation, and, therefore, we propose that co-administration with
adjuvant would provide the optimal effect.
To conclude, we propose that antigen needs to be detected and taken up at the same time as
adjuvant is sensed, but not necessarily co-administered. Most importantly, depending on the
time required for antigen to be disseminated, processed and detected, the timing of adjuvant
delivery must be adjusted in order to obtain optimal boosting of the subsequent immune
response.
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