Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska
Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska
Laboratories should report positive smears or positive cultures, and primary healthcare providers should report suspected or confirmed cases of TB to the health department, as specified in the “Reporting Tuberculosis” topic in the Surveillance section (2.6). Prompt reporting allows the health department to organize treatment and case management services and to initiate a contact investigation as quickly as possible. 4 For information on reporting, see the “Reporting Tuberculosis” topic in the Surveillance section 2.6. For laboratory services available in Alaska, contact the Mycobacteriology Department at 907-334-2139. Nucleic Acid Amplification Testing (NAAT): The ASPHL will perform testing on initial smear-positive respiratory specimens using the real-time TB PCR assay if the provider authorizes testing and the patient meets the criteria outlined below. The TB PCR Testing Authorization Form must be completed prior to testing. Additionally, ASPHL will perform TB PCR testing on smear-negative specimens from patients considered to be TB suspects upon provider request and pre-approval from the Alaska Tuberculosis Control Program. Patient Criteria Patient must have signs and symptoms of pulmonary TB Patient must be reported to the Alaska Tuberculosis Control Program as a TB suspect or TB case (907-269-8000) Patient must not have been diagnosed with TB or a non-tuberculous mycobacterial infection or received treatment within the last 12 months The TB PCR Testing Authorization Form is available in the Forms Section of the Manual 18.1. Refer to Table 3: PCR Testing Algorithm and Result Interpretation for information about interpreting the results of PCR (NAA Testing). A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Laborator y Services 12.5 Revised November 2012
Table 3: PCR Testing Algorithm and Result Interpretation Smear Result TB PCR Result Interpretation Mycobacterium tuberculosis complex DNA detected Presumed TB, pending culture results Smear Positive Use clinical judgment to determine whether to for AFB No Mycobacterium tuberculosis begin therapy while awaiting culture results. A complex DNA detected patient is presumed to have an infection with nontuberculosis mycobacteria, pending culture results. Use clinical judgment to determine whether to Mycobacterium tuberculosis complex DNA detected begin therapy while awaiting results of culture and other diagnostic tests. Currently available PCR tests are not sufficiently sensitive to exclude the Smear Negative diagnosis of TB. for AFB Use clinical judgment to determine whether to No Mycobacterium tuberculosis complex DNA detected begin therapy while awaiting results of culture and other diagnostic tests. Currently available PCR tests are not sufficiently sensitive to exclude the diagnosis of TB. A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Laborator y Services 12.6 Revised November 2012
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Laboratories should report positive smears or positive cultures, and primary healthcare<br />
providers should report suspected or confirmed cases <strong>of</strong> TB to the health department, as<br />
specified in the “Reporting <strong>Tuberculosis</strong>” topic in the Surveillance section (2.6). Prompt<br />
reporting allows the health department to organize treatment and case management<br />
services and to initiate a contact investigation as quickly as possible. 4<br />
For information on reporting, see the “Reporting <strong>Tuberculosis</strong>” topic in the<br />
Surveillance section 2.6.<br />
For laboratory services available in <strong>Alaska</strong>, contact the Mycobacteriology<br />
Department at 907-334-2139.<br />
Nucleic Acid Amplification Testing (NAAT):<br />
The ASPHL will perform testing on initial smear-positive respiratory specimens using the real-time TB<br />
PCR assay if the provider authorizes testing and the patient meets the criteria outlined below. The TB<br />
PCR Testing Authorization Form must be completed prior to testing. Additionally, ASPHL will perform<br />
TB PCR testing on smear-negative specimens from patients considered to be TB suspects upon<br />
provider request and pre-approval from the <strong>Alaska</strong> <strong>Tuberculosis</strong> Control <strong>Program</strong>.<br />
Patient Criteria<br />
Patient must have signs and symptoms <strong>of</strong> pulmonary TB<br />
Patient must be reported to the <strong>Alaska</strong> <strong>Tuberculosis</strong> Control <strong>Program</strong> as a TB suspect or TB<br />
case (907-269-8000)<br />
Patient must not have been diagnosed with TB or a non-tuberculous mycobacterial infection or<br />
received treatment within the last 12 months<br />
The TB PCR Testing Authorization Form is available in the Forms Section <strong>of</strong> the<br />
<strong>Manual</strong> 18.1.<br />
Refer to Table 3: PCR Testing Algorithm and Result Interpretation for information about interpreting<br />
the results <strong>of</strong> PCR (NAA Testing).<br />
A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Laborator y Services 12.5<br />
Revised November 2012