Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska
Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska
Outbreak Investigation If data from a contact investigation or surveillance indicate a potential outbreak, conduct an outbreak investigation. A tuberculosis (TB) outbreak warns of potential extensive transmission. An outbreak implies that 1) a TB patient was contagious, 2) contacts were exposed significantly, and 3) the interval since exposure has been sufficient for infection to progress to disease. An outbreak investigation involves several overlapping contact investigations, with a surge in the need for public health resources. More emphasis on active case finding is recommended, which sometimes means that more contacts than usual should have chest radiographs and specimen collection for mycobacteriology. Definition of a Tuberculosis Outbreak Definitions for TB outbreak are relative to the local context. Outbreak cases can be distinguished from other cases only when certain associations in time, location, patient characteristics, or Mycobacterium tuberculosis attributes (e.g., drug resistance or genotype) become apparent. In low-incidence jurisdictions, any temporal cluster is suspicious for an outbreak. A working definition of a potential TB outbreak is helpful for planning and response, and may include any of the following six criteria: Criteria based on surveillance and epidemiology: 1. An increase has occurred above the expected number of TB cases 2. During and because of a contact investigation, two or more contacts are identified as having TB disease, regardless of their assigned priority (i.e., high, medium, or low priority) 3. Any two or more cases occurring within one year of each other are discovered to be linked, and the linkage is established outside a contact investigation (e.g., two patients who received a diagnosis of TB disease outside a contact investigation are found to work in the same office and only one or neither of the persons was listed as a contact to the other) 4. A genotype cluster leads to discovery of one or more verified transmission links that were missed during a contact investigation within the prior two years Criteria based on program resources: Transmission is continuing despite adequate control efforts by the TB control program Contact investigation associated with increased cases requires additional outside help Deoxyribonucleic Acid Genotyping Deoxyribonucleic acid (DNA) genotyping is routinely done on all Alaska TB isolates at a regional genotyping laboratory. It is also a laboratory technique used by public health A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Contact Investigation 11.47 Revised November 2012
officials to distinguish between different strains of M. tuberculosis and to help assess the likelihood of TB transmission. Characterization of M. tuberculosis with DNA genotyping is a powerful tool for the following: 1. Surveillance of potential outbreaks 2. Confirming TB cases linked by traditional epidemiologic methods 3. Identifying clusters of patients infected with genetically related or identical strains of M. tuberculosis and determining common sources of infections 4. Identifying laboratory cross-contamination as the cause of misdiagnosis For more information regarding Deoxyribonucleic Acid Genotyping, refer to the National TB Controllers Association/CDC Advisory Group on Tuberculosis Genotyping. Guide to the Application of Genotyping to Tuberculosis and Control. Atlanta, GA: US department of Health and Human Services, CDC: June 2004. Available at: http://www.cdc.gov/tb/programs/genotyping/images/TBGenotypingGuide_June2004.pdf A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Contact Investigation 11.48 Revised November 2012
- Page 261 and 262: CDC. Module 9: “Patient Adherence
- Page 263 and 264: 36 New Jersey Medical School Nation
- Page 265 and 266: 75 CDC. Module 9: patient adherence
- Page 267 and 268: Introduction Purpose A contact inve
- Page 269 and 270: For roles and responsibilities, ref
- Page 271 and 272: Decision to Initiate a Contact Inve
- Page 273 and 274: chest radiographic findings that ar
- Page 275 and 276: In general, a contact investigation
- Page 277 and 278: Time Frames for Contact Investigati
- Page 279 and 280: Circumstances unique to Alaska may
- Page 281 and 282: Circumstances unique to Alaska may
- Page 283 and 284: Activity Purpose Maximum Time Inter
- Page 285 and 286: Infectious Period Determine the inf
- Page 287 and 288: In general, for the purposes of con
- Page 289 and 290: General Guidelines for Interviewing
- Page 291 and 292: Healthcare workers should remember
- Page 293 and 294: Index Patient with Positive Acid-Fa
- Page 295 and 296: Index Patient with Negative Acid-Fa
- Page 297 and 298: Contact Evaluation, Treatment, and
- Page 299 and 300: Definition of abbreviations: HIV =
- Page 301 and 302: Note: An IGRA may be used in place
- Page 303 and 304: When to Expand a Contact Investigat
- Page 305 and 306: Figure 7: EVALUATION, TREATMENT, AN
- Page 307 and 308: CDC’s “Framework of Program Eva
- Page 309 and 310: Definitions of abbreviations: AIDS
- Page 311: elease assay; LTBI = latent tubercu
- Page 315 and 316: References 1 ATS, CDC, IDSA. Contro
- Page 317 and 318: 44 CDC, NTCA. Guidelines for the in
- Page 319 and 320: Introduction Purpose Use this secti
- Page 321 and 322: Available Laboratory Tests Table 2:
- Page 323 and 324: Table 3: PCR Testing Algorithm and
- Page 325 and 326: Table 4: SPECIMEN COLLECTION METHOD
- Page 327 and 328: 5. If possible, send the specimen o
- Page 329 and 330: Specimen Shipment There are three m
- Page 331 and 332: Resources and References Resources
- Page 333 and 334: Patient Education CONTENTS Introduc
- Page 335 and 336: treatment, common side-effects of m
- Page 337 and 338: Education Topics During the initial
- Page 339 and 340: 10. Explain the signs and symptoms
- Page 341 and 342: Patient Education Materials Get th
- Page 343 and 344: References 1 CDC. Module 4: treatme
- Page 345 and 346: Introduction Purpose Use this secti
- Page 347 and 348: National Guidelines The following g
- Page 349 and 350: Transfer Notifications CONTENTS Int
- Page 351 and 352: For roles and responsibilities, ref
- Page 353 and 354: Follow-Up Type When to Initiate Not
- Page 355 and 356: Action Transfers Within Alaska Tran
- Page 357 and 358: Provide the patient with a. A copy
- Page 359 and 360: References 1 CDC. International not
- Page 361 and 362: Infection Control CONTENTS Introduc
<strong>of</strong>ficials to distinguish between different strains <strong>of</strong> M. tuberculosis and to help assess the<br />
likelihood <strong>of</strong> TB transmission. Characterization <strong>of</strong> M. tuberculosis with DNA genotyping<br />
is a powerful tool for the following:<br />
1. Surveillance <strong>of</strong> potential outbreaks<br />
2. Confirming TB cases linked by traditional epidemiologic methods<br />
3. Identifying clusters <strong>of</strong> patients infected with genetically related or identical strains <strong>of</strong><br />
M. tuberculosis and determining common sources <strong>of</strong> infections<br />
4. Identifying laboratory cross-contamination as the cause <strong>of</strong> misdiagnosis<br />
For more information regarding Deoxyribonucleic Acid Genotyping, refer to the National<br />
TB Controllers Association/CDC Advisory Group on <strong>Tuberculosis</strong> Genotyping. Guide to<br />
the Application <strong>of</strong> Genotyping to <strong>Tuberculosis</strong> and Control. Atlanta, GA: US department<br />
<strong>of</strong> Health and Human Services, CDC: June 2004. Available at:<br />
http://www.cdc.gov/tb/programs/genotyping/images/TBGenotypingGuide_June2004.pdf<br />
A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Contact Investigation 11.48<br />
Revised November 2012
Change language