Alaska Tuberculosis Program Manual - Epidemiology - State of Alaska

Antituberculosis
Drug
Rifampin (RIF)
Rifapentine
(RPT) is a
rifamycin
derivative with a
longer half-life.
Side-effects and
adverse reactions
are similar to
Rifampin.
Side Effects/
Adverse Reactions
Rash
Gastrointestinal upset
Hepatitis
Fever
Bleeding problems
Thrombocytopenia
Renal failure
Flu-like symptoms
Orange-colored body fluids
(secretions, urine, tears)
A L A S K A T U B E R C U L O S I S P R O G R A M M A N U A L Tr eatment of Latent Tuberculosis Infection
Revised November 2012
Monitoring Comments
In selected cases ((human immunodeficiency virus
[HIV] infection, history of liver disease, alcoholism,
and pregnancy), complete blood count, platelets
and liver function tests at baseline
aspartate aminotransferase [AST]
alanine aminotransferase [ALT]
serum bilirubin)
Repeat measurements if
Baseline results are abnormal
Patient has symptoms of adverse reactions
8.15
There are a number of drug interactions with potentially
serious consequences. Significant interactions with
methadone, birth control hormones, and many other
drugs.
Contraindicated or should be used with caution when
administered with protease inhibitors (PIs) and
nonnucleoside reverse transcriptase inhibitors
(NNRTIs). Reduces levels of many drugs (e.g., PIs,
NNRTIs, methadone, dapsone, ketoconazole, coumadin
derivatives, hormonal contraceptive, digitalis,
sulfonylureas, diazepam, ß-blockers, anticonvulsants,
and theophylline).
For more information, refer to “Section 7: Drug
Interactions” on page 45 in “Treatment of Tuberculosis”
at http://www.cdc.gov/mmwr/PDF/rr/rr5211.pdf .
Because information regarding rifamycin drug
interactions is evolving rapidly, consult the CDC’s
Division of Tuberculosis “News and Updates” Web page
at http://www.cdc.gov/tb/default.htm to obtain the most
up-to-date information.
Colors body fluids orange.
May permanently discolor soft contact lenses.