Surgery and Healing in the Developing World - Dartmouth-Hitchcock

Surgery and Healing in the Developing World - Dartmouth-Hitchcock Surgery and Healing in the Developing World - Dartmouth-Hitchcock

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Distribution and Incidence of Tropical Surgical Diseases 279 tis and sought treatment at the hospital in the Nigerian bush—and he was a very rare white visitor, a Peace Corps Volunteer from the Bronx! With this shift in patterns of recognition of common incidence conditions, I had learned of first-world rarities that might even have been nonexistent in my prior experience and listed them, but was even more impressed by the conditions with which I had become very familiar, strikingly absent. Both the causes of death and the incidence and complications of the infectious diseases called “tropical” were quite apparent in this setting, but to practice surgery, one needed to know the Western—or universal—fundamentals of surgery, and improvise in putting them into practice in the modifications required by the resource constraints. This “reprogramming” has been an essential part of clinical practice learning in each subsequent venue in which I have worked in the tropics. Presentation Pathology is often late in its presentation to the attention of health care workers. This is a simple statement often reiterated in regard to tropical surgery conditions. What it means is that, far from being a challenge, diagnosis is often apparent at a glance, or a sniff, and not necessarily by a physician. Few of the primary presentations are subtle. The findings are so obvious, that simply exposing, or pointing is all the “History and Physical” examination needed in many wordless encounters without need for translation. An adult with a cleft lip or a child with an extremity bent in a right angle are not diagnostic dilemmas. An outcast woman sitting outside the clinic door and reeking of urea-splitting organisms hardly need be examined to determine that she has a long-standing vesicovaginal fistula. Some of these unfortunate patients presenting in such a late stage of disease afford a fascinating “window” on the natural history of some conditions never allowed to deteriorate before repair in other, more fortunate, parts of the world. I had once seen a man with a rather unique situation that was at first puzzling—a scrotal ileostomy. I then realized I was looking at the natural history of incarcerated inguinal hernia that strangulate with the only unlikely outcome that could still result in his survival. I had encountered unusual physical findings associated with filariasis that were advanced features of the disease. The “hanging groin” was not a clinical feature I had encountered before my experience in filariasis endemic areas, where I had also learned of onchocerciasis nodules appearing everywhere where a tumor might be suspected, including intracranially. I discovered chyluria and a number of other late stage features of several of the filarial complications. When I had accommodated the spectrum of filariasis, I saw it everywhere, even where it was not. I had encountered elephantiasis of the extremities in areas where I thought it odd that there had been no filariasis being recorded. One such patient was seen in Ecuador, where he was completely disabled by the distortion of his legs, and only later did I learn that the characteristic elephantiasis I had identified as filarial in origin could also result for silica lymphangitic obstruction in pedoconiosis, or “mossy foot” 8 for which an entire surgical treatment and prevention project is supported in an Ethiopian hospital. Environmental Conditions There are but two seasons in the tropical latitudes, marked by extremes of inundation and desiccation, with illnesses and hygiene conditions reflecting water-borne 27

27 280 Surgery and Healing in the Developing World or water-lack cycles. The dry and rainy seasons have special implications for tropical surgery and the spoilage of some equipment and the kinds of environmental conditions that will compromise patient hygiene. 9 The tropical days do not vary in length as much as they do in the temperate zones, so that the tropics should not be thought of as a European or North American summer day, but more like an Equatorial equinox in these latitudes, with limited periods of daylight during which much of the work must be accomplished in the scarcity of artificial illumination. This also has implications for the surgical workload that is often limited by the daylight stored as solar power. The other geographic features that determine the micro-climatic conditions include altitude, proximity to the sea, rivers, lakes or deserts, prevailing wind and monsoons or harmattans, and volcanic or rainforest soils. Altitude has a major role in the ambient temperature, a circumstance that has impressed itself on me as I have stood on “Equatorial glaciers” on multiple points around the earth’s high mountains well within the tropics, as, for example, at 00.00 on Kilimanjaro. It has seemed to me to be confusing and perhaps an unfair or unkind trick, if not inexplicable, that one can suffer both frostbite and the rigors of a malarial fever in the same setting. Volcanic soils, the notoriously poor soils of rainforests with little organic nutrients or soluble minerals within them, and mountain soils have been inadequate as sources of both micronutrients and any sustainable yield of macronutrient calories. These marginal lands have very limited carrying capacity, yet are pressed as home for ever increasing density of populations. One result of these conditions is endemic hypothyroidism and goiter around the globe’s equatorial belt10 in areas of iodine deficiency disorders. Iron deficiency is compounded by the burden of helminthic disease, such as hookworm11 which causes additional attrition in energy and its utilization in learning and industriousness. Floods may affect some parts of the tropical world when no rain has been experienced, if they are within the pattern of some much larger movement of wind and water—such as the flooding of the Sudh in the Sudan from the Nile’s output of highland Ethiopia precipitation, or the Himalayan-generated monsoon seasons half a world away. These global patterns are subject to periodic perturbation also, as has been seen with the worldwide disruption following El Nino. Endemic Disease of Surgical Consequence, Superimposable on these Geographic Constraints It has been well-known since the time of Manson that malaria is a mosquito-born illness and that the patterns of much of tropical disease could be unlocked by a knowledge of the entomology that underlay some diseases. This was not only true for the plasmodia in their distribution with the seasonally cyclic Anopheles mosquito breeding and feeding patterns, but second and third order diseases as well. There were diseases directly related to the malaria—such as the nephritic syndrome of blackwater fever—but also those genetic traits selected by the partial resistance conferred by hemoglobinopathies that also produced blood dyscrasias such as sickle cell disease and Mediterranean hemoglobinopathies. One of the pioneers of the kind of epidemiology that led to clues as to the origins of some kinds of tropical noncommunicable disease was Denis Burkitt, whose Great Safari in a continuously-repaired station wagon brought back information of the incidence, frequency, and pattern of an unusual maxillo-facial and visceral child-

Distribution <strong>and</strong> Incidence of Tropical Surgical Diseases<br />

279<br />

tis <strong>and</strong> sought treatment at <strong>the</strong> hospital <strong>in</strong> <strong>the</strong> Nigerian bush—<strong>and</strong> he was a very<br />

rare white visitor, a Peace Corps Volunteer from <strong>the</strong> Bronx!<br />

With this shift <strong>in</strong> patterns of recognition of common <strong>in</strong>cidence conditions, I<br />

had learned of first-world rarities that might even have been nonexistent <strong>in</strong> my prior<br />

experience <strong>and</strong> listed <strong>the</strong>m, but was even more impressed by <strong>the</strong> conditions with<br />

which I had become very familiar, strik<strong>in</strong>gly absent. Both <strong>the</strong> causes of death <strong>and</strong><br />

<strong>the</strong> <strong>in</strong>cidence <strong>and</strong> complications of <strong>the</strong> <strong>in</strong>fectious diseases called “tropical” were<br />

quite apparent <strong>in</strong> this sett<strong>in</strong>g, but to practice surgery, one needed to know <strong>the</strong> Western—or<br />

universal—fundamentals of surgery, <strong>and</strong> improvise <strong>in</strong> putt<strong>in</strong>g <strong>the</strong>m <strong>in</strong>to<br />

practice <strong>in</strong> <strong>the</strong> modifications required by <strong>the</strong> resource constra<strong>in</strong>ts. This “reprogramm<strong>in</strong>g”<br />

has been an essential part of cl<strong>in</strong>ical practice learn<strong>in</strong>g <strong>in</strong> each subsequent<br />

venue <strong>in</strong> which I have worked <strong>in</strong> <strong>the</strong> tropics.<br />

Presentation<br />

Pathology is often late <strong>in</strong> its presentation to <strong>the</strong> attention of health care workers.<br />

This is a simple statement often reiterated <strong>in</strong> regard to tropical surgery conditions.<br />

What it means is that, far from be<strong>in</strong>g a challenge, diagnosis is often apparent at a<br />

glance, or a sniff, <strong>and</strong> not necessarily by a physician. Few of <strong>the</strong> primary presentations<br />

are subtle. The f<strong>in</strong>d<strong>in</strong>gs are so obvious, that simply expos<strong>in</strong>g, or po<strong>in</strong>t<strong>in</strong>g is all<br />

<strong>the</strong> “History <strong>and</strong> Physical” exam<strong>in</strong>ation needed <strong>in</strong> many wordless encounters without<br />

need for translation. An adult with a cleft lip or a child with an extremity bent <strong>in</strong><br />

a right angle are not diagnostic dilemmas. An outcast woman sitt<strong>in</strong>g outside <strong>the</strong><br />

cl<strong>in</strong>ic door <strong>and</strong> reek<strong>in</strong>g of urea-splitt<strong>in</strong>g organisms hardly need be exam<strong>in</strong>ed to determ<strong>in</strong>e<br />

that she has a long-st<strong>and</strong><strong>in</strong>g vesicovag<strong>in</strong>al fistula.<br />

Some of <strong>the</strong>se unfortunate patients present<strong>in</strong>g <strong>in</strong> such a late stage of disease<br />

afford a fasc<strong>in</strong>at<strong>in</strong>g “w<strong>in</strong>dow” on <strong>the</strong> natural history of some conditions never allowed<br />

to deteriorate before repair <strong>in</strong> o<strong>the</strong>r, more fortunate, parts of <strong>the</strong> world. I had<br />

once seen a man with a ra<strong>the</strong>r unique situation that was at first puzzl<strong>in</strong>g—a scrotal<br />

ileostomy. I <strong>the</strong>n realized I was look<strong>in</strong>g at <strong>the</strong> natural history of <strong>in</strong>carcerated <strong>in</strong>gu<strong>in</strong>al<br />

hernia that strangulate with <strong>the</strong> only unlikely outcome that could still result<br />

<strong>in</strong> his survival.<br />

I had encountered unusual physical f<strong>in</strong>d<strong>in</strong>gs associated with filariasis that were<br />

advanced features of <strong>the</strong> disease. The “hang<strong>in</strong>g gro<strong>in</strong>” was not a cl<strong>in</strong>ical feature I had<br />

encountered before my experience <strong>in</strong> filariasis endemic areas, where I had also learned<br />

of onchocerciasis nodules appear<strong>in</strong>g everywhere where a tumor might be suspected,<br />

<strong>in</strong>clud<strong>in</strong>g <strong>in</strong>tracranially. I discovered chyluria <strong>and</strong> a number of o<strong>the</strong>r late stage features<br />

of several of <strong>the</strong> filarial complications.<br />

When I had accommodated <strong>the</strong> spectrum of filariasis, I saw it everywhere, even<br />

where it was not. I had encountered elephantiasis of <strong>the</strong> extremities <strong>in</strong> areas where I<br />

thought it odd that <strong>the</strong>re had been no filariasis be<strong>in</strong>g recorded. One such patient<br />

was seen <strong>in</strong> Ecuador, where he was completely disabled by <strong>the</strong> distortion of his legs,<br />

<strong>and</strong> only later did I learn that <strong>the</strong> characteristic elephantiasis I had identified as<br />

filarial <strong>in</strong> orig<strong>in</strong> could also result for silica lymphangitic obstruction <strong>in</strong> pedoconiosis,<br />

or “mossy foot” 8 for which an entire surgical treatment <strong>and</strong> prevention project is<br />

supported <strong>in</strong> an Ethiopian hospital.<br />

Environmental Conditions<br />

There are but two seasons <strong>in</strong> <strong>the</strong> tropical latitudes, marked by extremes of <strong>in</strong>undation<br />

<strong>and</strong> desiccation, with illnesses <strong>and</strong> hygiene conditions reflect<strong>in</strong>g water-borne<br />

27

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