Surgery and Healing in the Developing World - Dartmouth-Hitchcock

Surgery and Healing in the Developing World - Dartmouth-Hitchcock Surgery and Healing in the Developing World - Dartmouth-Hitchcock

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18 170 Surgery and Healing in the Developing World can be crossmatched one time without it. It should be emphasized in the developing world where coronary artery disease is rare, most patients can tolerate a packed cell volume of 20% or even less if adequate intravascular volume is maintained. The preferred blood transfusion is, of course, autotransfusion. The operating theater on a very tight budget (the nature we are discussing) would not have access to the very expensive cell savers in many modern theaters but can certainly afford a stainless steel soup ladle. Blood in the abdomen from a ruptured tubal pregnancy or ruptured spleen, for example, where there is no contamination from a ruptured viscus, can be rapidly scooped up—without hemolysis from suctioning—run through a gauze filter and infused through a blood-giving filter. A good microbiology lab is helpful, especially if antibiotic abuse is prevalent. Such a lab however may be unavailable, and there are helpful hints to be obtained from a Gram stain. A positive blood culture may be assumed if one spins a packed cell volume microhematocrit tube and breaks it at the buffy coat and finds organisms in the buffy coat. If an odor is present on an intraabdominal abscess, one can assume there are anaerobes present. The Gram stain can predict the type with fair accuracy that, if it is a gram negative bacillus, it is likely to be Bacteroides. If it is a Gram positive coccus, it is likely an anaerobic streptococcus. If it is a Gram positive bacillus, then one of the Clostridium species is likely present. In this era a glucometer should be in every lab even though the reagent strips are expensive. When a history suggests a need, spend a strip. Make sure the nocturia is from benign prostatic hypertrophy and not diabetes if you are planning prostate surgery. In an ideal world there would be many tests available in every lab. Yet in many countries the entire health budget per capita is spent with one basic lab test per person per year. Anesthesia Cost Containment A complete discussion of anesthesia is beyond the scope of this chapter, but there are some areas where cost savings can be safely achieved. There is not a surgeon practicing in the developing world who has not said, “Thank God for ketamine.” The author was present at the first announcement of the drug by pharmacologists at the University of Michigan in the early 1960s. Not even they could have predicted how many lives worldwide would be saved with ketamine anesthesia. A wide range of operations from reconstructive to emergency surgery to obstetric and routine general surgery are possible with ketamine at relatively low cost. Ketamine is best used with anticholinergics like atropine to decrease secretions. In adults the addition of diazepam will reduce the incidence of emergence phenomena. Oximetry adds greatly to the safety of ketamine. If hypoxia occurs, airway manipulation with a jaw thrust usually is all that is required although occasional oxygen by mask is necessary as well. Surgeons and anesthesiologists must recall however that this anesthetic is contraindicated with increased intracranial pressure, a history of seizure disorders, uncontrolled hypertension and procedures in the upper airway such as bronchoscopy for foreign bodies. In these situations the least expensive alternatives are local block if feasible, spinal anesthesia if appropriate, ether or fluothane. The newer drugs like ethrane and propofol would rapidly bankrupt a hospital. The author is aware of and has seen in use a technique to do two consecutive cases with one vial of spinal anesthetic, particularly with the less readily available long-acting agents

Guide to the Operating Theater on $25 a Patient 171 such as pontocaine. After the first dose of 1 ml or less is drawn up, a sterile cotton ball is used to cover that vial for use a couple of hours later. While not ideal, this does work if a hospital is down to its last vials. An oxygen concentrator is very cost-effective, especially in areas where bottled oxygen is difficult to obtain or is very expensive. An oxygen concentration of over 30% can be achieved reliably. With a cost-effective operating theater and laboratory and anesthesia service in place, let us now consider specific disease entities where cost-savings and improvisations can be made. For a comprehensive review of the basic work-up and treatment of these diseases, standard texts and other chapters of this book should be consulted. Burns Care of burns is an extremely expensive, time-consuming process. Yet burns occur all too frequently in areas where cooking is done on open fires. Mortality is often high and the morbidity of a tragic fire can lead to a lifetime of misery. Aggressive treatment can limit those however. After the resuscitation phase, aggressive wound care can make a major difference in the outcome and can save long-term costs. For example, early excision and grafting of a third degree burn greatly speeds up the healing process. A skin grafting blade is used to progressively shave off the nonviable outer layers till a healthy, bleeding bed is apparent. One must be sure all nonviable dermis is shaved off, even if it necessary in some places to go to the subcutaneous tissue. It can be especially advantageous in the hand and foot. Burns over 15-20% probably are not candidates for this method which is associated with considerable bleeding, but the technique greatly accelerates healing and reduces cost. Dressings are applied and primary grafting are done in a day or two. There is a huge difference in the costs of various dermatomes. Brown dermatomes are favored by many surgeons but are expensive, require a pressure power source and use fairly expensive blades that can be used only a few times. The Padgett is also popular but relatively expensive. The very popular Humby knife is an excellent substitute and should be in every operating room in the developing world. But the cost of their blades is significant too, and at times they will be “out-of-stock’, an all too frequent phrase in many places. The Weck dermatome fills a big vacuum in that it is inexpensive and uses very inexpensive blades. The drawback is the maximal width of only 5.5 cm for the graft. Meshing or “pie-crusting” can increase that however. An assistant has to create tension and a slight convex curve to facilitate its use (Fig. 1). The author greatly favors use of the povidone iodine solution as the lubricant for taking the graft rather than sterile mineral oil which has been found to stay in the graft site for a prolonged time. The povidone-iodine solution is applied immediately before taking the graft. Topical therapy for second degree burns not treated with early excision can be very expensive and the widely used silver sulfadiazine is difficult to keep in stock if major burns are being treated. One readily available and inexpensive substitute is that of honey gauze which has compared favorably with other standard topical agents. The gauze is prepared by dipping sterile gauze in slightly warmed, unprocessed honey. The honey gauze is covered with absorbent dressing and changed every 2 days. Needless to say, mosquito nets must be used for all burns and certainly all those being treated with honey. For very superficial second degree burns, amniotic membrane rinsed with saline and then soaked in antibiotics has worked as well as the very expensive porcine xenograft, but in an era of rampant HIV in many areas, this is probably not safe, even if the donor’s HIV status is known to be negative. Superficial 18

Guide to <strong>the</strong> Operat<strong>in</strong>g Theater on $25 a Patient<br />

171<br />

such as pontoca<strong>in</strong>e. After <strong>the</strong> first dose of 1 ml or less is drawn up, a sterile cotton<br />

ball is used to cover that vial for use a couple of hours later. While not ideal, this<br />

does work if a hospital is down to its last vials.<br />

An oxygen concentrator is very cost-effective, especially <strong>in</strong> areas where bottled<br />

oxygen is difficult to obta<strong>in</strong> or is very expensive. An oxygen concentration of over<br />

30% can be achieved reliably. With a cost-effective operat<strong>in</strong>g <strong>the</strong>ater <strong>and</strong> laboratory<br />

<strong>and</strong> anes<strong>the</strong>sia service <strong>in</strong> place, let us now consider specific disease entities where<br />

cost-sav<strong>in</strong>gs <strong>and</strong> improvisations can be made. For a comprehensive review of <strong>the</strong><br />

basic work-up <strong>and</strong> treatment of <strong>the</strong>se diseases, st<strong>and</strong>ard texts <strong>and</strong> o<strong>the</strong>r chapters of<br />

this book should be consulted.<br />

Burns<br />

Care of burns is an extremely expensive, time-consum<strong>in</strong>g process. Yet burns occur<br />

all too frequently <strong>in</strong> areas where cook<strong>in</strong>g is done on open fires. Mortality is often<br />

high <strong>and</strong> <strong>the</strong> morbidity of a tragic fire can lead to a lifetime of misery. Aggressive<br />

treatment can limit those however. After <strong>the</strong> resuscitation phase, aggressive wound<br />

care can make a major difference <strong>in</strong> <strong>the</strong> outcome <strong>and</strong> can save long-term costs. For<br />

example, early excision <strong>and</strong> graft<strong>in</strong>g of a third degree burn greatly speeds up <strong>the</strong><br />

heal<strong>in</strong>g process. A sk<strong>in</strong> graft<strong>in</strong>g blade is used to progressively shave off <strong>the</strong> nonviable<br />

outer layers till a healthy, bleed<strong>in</strong>g bed is apparent. One must be sure all nonviable<br />

dermis is shaved off, even if it necessary <strong>in</strong> some places to go to <strong>the</strong> subcutaneous<br />

tissue. It can be especially advantageous <strong>in</strong> <strong>the</strong> h<strong>and</strong> <strong>and</strong> foot. Burns over 15-20%<br />

probably are not c<strong>and</strong>idates for this method which is associated with considerable<br />

bleed<strong>in</strong>g, but <strong>the</strong> technique greatly accelerates heal<strong>in</strong>g <strong>and</strong> reduces cost. Dress<strong>in</strong>gs<br />

are applied <strong>and</strong> primary graft<strong>in</strong>g are done <strong>in</strong> a day or two. There is a huge difference<br />

<strong>in</strong> <strong>the</strong> costs of various dermatomes. Brown dermatomes are favored by many surgeons<br />

but are expensive, require a pressure power source <strong>and</strong> use fairly expensive<br />

blades that can be used only a few times. The Padgett is also popular but relatively<br />

expensive. The very popular Humby knife is an excellent substitute <strong>and</strong> should be <strong>in</strong><br />

every operat<strong>in</strong>g room <strong>in</strong> <strong>the</strong> develop<strong>in</strong>g world. But <strong>the</strong> cost of <strong>the</strong>ir blades is significant<br />

too, <strong>and</strong> at times <strong>the</strong>y will be “out-of-stock’, an all too frequent phrase <strong>in</strong> many<br />

places. The Weck dermatome fills a big vacuum <strong>in</strong> that it is <strong>in</strong>expensive <strong>and</strong> uses<br />

very <strong>in</strong>expensive blades. The drawback is <strong>the</strong> maximal width of only 5.5 cm for <strong>the</strong><br />

graft. Mesh<strong>in</strong>g or “pie-crust<strong>in</strong>g” can <strong>in</strong>crease that however. An assistant has to create<br />

tension <strong>and</strong> a slight convex curve to facilitate its use (Fig. 1). The author greatly<br />

favors use of <strong>the</strong> povidone iod<strong>in</strong>e solution as <strong>the</strong> lubricant for tak<strong>in</strong>g <strong>the</strong> graft ra<strong>the</strong>r<br />

than sterile m<strong>in</strong>eral oil which has been found to stay <strong>in</strong> <strong>the</strong> graft site for a prolonged<br />

time. The povidone-iod<strong>in</strong>e solution is applied immediately before tak<strong>in</strong>g <strong>the</strong> graft.<br />

Topical <strong>the</strong>rapy for second degree burns not treated with early excision can be<br />

very expensive <strong>and</strong> <strong>the</strong> widely used silver sulfadiaz<strong>in</strong>e is difficult to keep <strong>in</strong> stock if<br />

major burns are be<strong>in</strong>g treated. One readily available <strong>and</strong> <strong>in</strong>expensive substitute is<br />

that of honey gauze which has compared favorably with o<strong>the</strong>r st<strong>and</strong>ard topical agents.<br />

The gauze is prepared by dipp<strong>in</strong>g sterile gauze <strong>in</strong> slightly warmed, unprocessed honey.<br />

The honey gauze is covered with absorbent dress<strong>in</strong>g <strong>and</strong> changed every 2 days. Needless<br />

to say, mosquito nets must be used for all burns <strong>and</strong> certa<strong>in</strong>ly all those be<strong>in</strong>g<br />

treated with honey. For very superficial second degree burns, amniotic membrane<br />

r<strong>in</strong>sed with sal<strong>in</strong>e <strong>and</strong> <strong>the</strong>n soaked <strong>in</strong> antibiotics has worked as well as <strong>the</strong> very<br />

expensive porc<strong>in</strong>e xenograft, but <strong>in</strong> an era of rampant HIV <strong>in</strong> many areas, this is<br />

probably not safe, even if <strong>the</strong> donor’s HIV status is known to be negative. Superficial<br />

18

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