October 15, 2012 - City of Laredo

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PRODUCT NAME: '[RIETHYLENE GLYCOL
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V. HEALTH HAZARD DATA
EXPOSURE LIMITIS): ' Ethylene glycol: 100 mgIm3 139.4 ppm) Ceiling, Aerosol, ACGlH
127 mglm3 (50 ppm) Ceiling, Vapor and Mist, OSHA
UNION CARBIDE RECOMMENDATION:
100 rnglm3 (39.4 ppm) Ceiling, Aerosol and Vapor
SWALLOWING: I Abdominal discomfort, nausea and bomiting may occur.
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INHALATION: j
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SKIN ABSORPTIO~N. No evidence of harmful effects from available information.
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Short-term harmful health effects are not expected from vapor generated at
ambient temperature.
No evidence of short-term harmful effects from respirable aerosol based on
available informarion.
See "Effects of Repeated Overexposure."
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SKIN CONTACT: ! Sustained contact may cause mild local redness.
No harmful effects expected from liquid.
Vapor or mist may be irritating, experienced as discomfort, excess blinklng
and tear production, with excess redness of the conjunctiva.
I Exposure to high concentratlons of aerosol generated at room temperature may
I cause lung injury and liver dysfunction.
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MEDICAL CONDITION^ AGGRAVATED BY OVEREXPOSURE:
A knowledge of the available tox~cology information and of the physical and
chemical properties of the rnater~al suggests that overexposure is unlikely to
aggravate exis:ing medical conditions.
SIGNIFICANT LABOR~~TORY DATA WITH POSSIBLE RELEVANCE TO HUMAN
HEALTH HAZARD EVALUATION:
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Triethylene glycol was given to rats by inclusion in the diet for 90 days at
concentrations of 10,000. 20,000 or 50,000 pprn. At the highest dose, there
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were decreases in body welght. Physiologic responses to these high doses were
observed in kidney weight and urinalysis. No specific organ toxicity was seen.
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In a 9-day repeated inhalation exposure (6 hourslday) study with rats, mortal-
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ity occurred at 4284 mgim3; at 201 1 mgIm3 effects included eye irr~tatlon and
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increased alanine aminotransferase and alkaline phosphatase activities; at
494 rnglm3 there was slightly increased alkaline phosphatase activity.
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In a subsequent 9-day (nose-only) repeated aerosol study, the only effect
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noted was slight (not statistically significant) decrease in body weight gain
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at 517 and 1036 mglm3, but not at 102 mglm3. No indications of local or
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systemic target organ toxicjty were noted.
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There was no evidence in developmental toxicity studies for either embryotoxic
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or teratogenic effects in mice or rats given rriethylene glycol by gavage.
Maternal toxicity was seen as reduced body weight and food comsurnptlon,
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increased water comsurnption, and increased relative kidney weight wlth rats,