Metabolomics - CERM

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*Lattosio Spettro 1 H NMR di latte Lecitina Creatina Glicerolo Acidi grassi insaturi * Citrato Acidi grassi
Spettro 1 H NMR di marche diverse Non si osservano differenze negli spettri di latte fresco intero tra marche diverse. Il Granarolo parzialmente scremato presenta picchi meno intensi nella zona degli acidi grassi (frecce). Maremma Mukki Granarolo
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Metabolomics Leonardo Tenori FiorGe
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“La metabolomica è l’ultima na
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Metabolomica: la nuova frontiera
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Metabonomics “…measurement of t
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Metabolomica: alcuni obiettivi Valu
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Metabolomica: alcuni obiettivi Scop
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The metabolome consists of what? Sm
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C om p ound class N u m b er C om p
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Why 1 µM? Equals ~200 ng/mL Limit
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Medical Metabolomics Generate metab
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Traditional Metabolite Analysis HPL
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What’s the Difference Between Met
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Advantages Measure multiple (10’s
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2 Routes to Metabolomics Two approa
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Benefits of analyzing the metabolom
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Advantages: Use of NMR in Non-destr
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Raccolta e stoccaggio dei campioni
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NMR A typical 950-MHz H NMR spectru
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Profilo 1 H NMR di urina umana
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Profilo di siero umano Proteins + L
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Data analysis - approach Classify N
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PCA Unsupervised Multivariate analy
Page 51 and 52: PCA Loadings Plot • Loadings plot
Page 53 and 54: SIMCA Supervised learning method ba
Page 55 and 56: OPLS OPLS method is a recent modifi
Page 57 and 58: Targeted profiling Targeted metabol
Page 59 and 60: Databases
Page 61 and 62: Effetto della dieta Trimetilammina
Page 63 and 64: Effetto delle patologie Campioni di
Page 65 and 66: METabolomic REFerence The METREF pr
Page 67 and 68: Ind 1 Ind 2 METabolomic REFerence G
Page 69 and 70: METabolomic REFerence Dendrogram of
Page 71 and 72: METabolomic REFerence An individual
Page 73 and 74: METabolomic REFerence 2 Experimenta
Page 75 and 76: METabolomic REFerence 2 2005 collec
Page 77 and 78: Un “salto” metabolico Evoluzion
Page 79 and 80: Celiac Disease Metabolomics Experim
Page 81 and 82: Celiac Disease Metabolomics Note: b
Page 83 and 84: Celiac Disease Metabolomics Celiac
Page 85 and 86: Celiac Disease Metabolomics Cluster
Page 87 and 88: Potential celiac disease Subjects:
Page 89 and 90: Celiachia Potenziale Celiaci - Sani
Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
Page 93 and 94: PRODOTTI DI OSSIDAZIONE QUASI ASSEN
Page 95 and 96: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
Page 97: Metabolomica del latte Recente inte
Page 101 and 102: Formato Spettro 1 H NMR di latte di
Page 103 and 104: formato Formato acetato e piruvato
Page 105: Disponibilità di Tesi in METABOLOM
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Metabolomics - CERM

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