Metabolomics - CERM

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CARATTERIZZAZIONE GEOGRAFICA ( 1 H): OLI DEL CENTRO-NORD LDA L.Mannina, M.Patumi, N.Proietti, D.Bassi, A.L.Segre, Journal of Agriculture and Food Chemistry, (2001), 49, 2687- 2696
Metabolomica del latte Recente interesse per l’applicazione della metabolomica all’analisi del latte e dei suoi derivati
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Metabolomics Leonardo Tenori FiorGe
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“La metabolomica è l’ultima na
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Metabolomica: la nuova frontiera
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Metabonomics “…measurement of t
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Metabolomica: alcuni obiettivi Valu
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Metabolomica: alcuni obiettivi Scop
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The metabolome consists of what? Sm
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C om p ound class N u m b er C om p
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Why 1 µM? Equals ~200 ng/mL Limit
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Medical Metabolomics Generate metab
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Traditional Metabolite Analysis HPL
Page 23 and 24:
What’s the Difference Between Met
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Advantages Measure multiple (10’s
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2 Routes to Metabolomics Two approa
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Benefits of analyzing the metabolom
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Advantages: Use of NMR in Non-destr
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Raccolta e stoccaggio dei campioni
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NMR A typical 950-MHz H NMR spectru
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Profilo 1 H NMR di urina umana
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Profilo di siero umano Proteins + L
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Data analysis - approach Classify N
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PCA Unsupervised Multivariate analy
Page 51 and 52: PCA Loadings Plot • Loadings plot
Page 53 and 54: SIMCA Supervised learning method ba
Page 55 and 56: OPLS OPLS method is a recent modifi
Page 57 and 58: Targeted profiling Targeted metabol
Page 59 and 60: Databases
Page 61 and 62: Effetto della dieta Trimetilammina
Page 63 and 64: Effetto delle patologie Campioni di
Page 65 and 66: METabolomic REFerence The METREF pr
Page 67 and 68: Ind 1 Ind 2 METabolomic REFerence G
Page 69 and 70: METabolomic REFerence Dendrogram of
Page 71 and 72: METabolomic REFerence An individual
Page 73 and 74: METabolomic REFerence 2 Experimenta
Page 75 and 76: METabolomic REFerence 2 2005 collec
Page 77 and 78: Un “salto” metabolico Evoluzion
Page 79 and 80: Celiac Disease Metabolomics Experim
Page 81 and 82: Celiac Disease Metabolomics Note: b
Page 83 and 84: Celiac Disease Metabolomics Celiac
Page 85 and 86: Celiac Disease Metabolomics Cluster
Page 87 and 88: Potential celiac disease Subjects:
Page 89 and 90: Celiachia Potenziale Celiaci - Sani
Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
Page 93 and 94: PRODOTTI DI OSSIDAZIONE QUASI ASSEN
Page 95: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
Page 99 and 100: Spettro 1 H NMR di marche diverse N
Page 101 and 102: Formato Spettro 1 H NMR di latte di
Page 103 and 104: formato Formato acetato e piruvato
Page 105: Disponibilità di Tesi in METABOLOM
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