Metabolomics - CERM

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Celiac Disease <strong>Metabolomics</strong> Follow-up analysis Samples at 3, 6, 9, 12 months from diagnosis Serum and urines Metabolite profiling Patter recognition Using CPMG sera, all but one samples after 12 months on a gluten-free diet are classified as normal!
Celiac Disease <strong>Metabolomics</strong> Clusterization of Celiac and Healthy subject serum spectra Bertini, I.; Calabrò, A.; De Carli, V.; Luchinat, C.; Nepi, S.; Porfirio, B.; Renzi, D.; Saccenti, E.; Tenori, L. The metabonomic signature of celiac disease, J. Proteome Res. 2009, 8(1), 170
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Metabolomics Leonardo Tenori FiorGe
Page 3 and 4:
“La metabolomica è l’ultima na
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Metabolomica: la nuova frontiera
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Metabonomics “…measurement of t
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Metabolomica: alcuni obiettivi Valu
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Metabolomica: alcuni obiettivi Scop
Page 13 and 14:
The metabolome consists of what? Sm
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C om p ound class N u m b er C om p
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Why 1 µM? Equals ~200 ng/mL Limit
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Medical Metabolomics Generate metab
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Traditional Metabolite Analysis HPL
Page 23 and 24:
What’s the Difference Between Met
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Advantages Measure multiple (10’s
Page 27 and 28:
2 Routes to Metabolomics Two approa
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Benefits of analyzing the metabolom
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Advantages: Use of NMR in Non-destr
Page 33 and 34: Raccolta e stoccaggio dei campioni
Page 35 and 36: NMR A typical 950-MHz H NMR spectru
Page 37 and 38: Profilo 1 H NMR di urina umana
Page 39 and 40: Profilo di siero umano Proteins + L
Page 41 and 42: Data analysis - approach Classify N
Page 43: PCA Unsupervised Multivariate analy
Page 51 and 52: PCA Loadings Plot • Loadings plot
Page 53 and 54: SIMCA Supervised learning method ba
Page 55 and 56: OPLS OPLS method is a recent modifi
Page 57 and 58: Targeted profiling Targeted metabol
Page 59 and 60: Databases
Page 61 and 62: Effetto della dieta Trimetilammina
Page 63 and 64: Effetto delle patologie Campioni di
Page 65 and 66: METabolomic REFerence The METREF pr
Page 67 and 68: Ind 1 Ind 2 METabolomic REFerence G
Page 69 and 70: METabolomic REFerence Dendrogram of
Page 71 and 72: METabolomic REFerence An individual
Page 73 and 74: METabolomic REFerence 2 Experimenta
Page 75 and 76: METabolomic REFerence 2 2005 collec
Page 77 and 78: Un “salto” metabolico Evoluzion
Page 79 and 80: Celiac Disease Metabolomics Experim
Page 81 and 82: Celiac Disease Metabolomics Note: b
Page 83: Celiac Disease Metabolomics Celiac
Page 87 and 88: Potential celiac disease Subjects:
Page 89 and 90: Celiachia Potenziale Celiaci - Sani
Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
Page 93 and 94: PRODOTTI DI OSSIDAZIONE QUASI ASSEN
Page 95 and 96: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
Page 97 and 98: Metabolomica del latte Recente inte
Page 99 and 100: Spettro 1 H NMR di marche diverse N
Page 101 and 102: Formato Spettro 1 H NMR di latte di
Page 103 and 104: formato Formato acetato e piruvato
Page 105: Disponibilità di Tesi in METABOLOM
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