Metabolomics - CERM
Metabolomics - CERM Metabolomics - CERM
METabolomic REFerence Convex hulls of 22 donors in the three most significant PCA PCA-CA CA dimensions PCA for data reduction CA for obtain well separated clusters KNN for classification 99% accuracy in montecarlo cross validation “natural” gender discrimination MALE FEMALE Assfalg, Bertini, Colangiuli, Luchinat, Schäfer, Schütz, Spraul, PNAS PNAS, , 2008 2008, , 105, 1420 1420-4
METabolomic REFerence Dendrogram of the 22 donors on the 21 21-dimensional dimensional PCA-CA PCA CA subspace Assfalg, Bertini, Colangiuli, Luchinat, Schäfer, Schütz, Spraul, PNAS PNAS, , 2008 2008, , 105, 1420 1420-4
- Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
- Page 19 and 20: Medical Metabolomics Generate metab
- Page 21 and 22: Traditional Metabolite Analysis HPL
- Page 23 and 24: What’s the Difference Between Met
- Page 25 and 26: Advantages Measure multiple (10’s
- Page 27 and 28: 2 Routes to Metabolomics Two approa
- Page 29 and 30: Benefits of analyzing the metabolom
- Page 31 and 32: Advantages: Use of NMR in Non-destr
- Page 33 and 34: Raccolta e stoccaggio dei campioni
- Page 35 and 36: NMR A typical 950-MHz H NMR spectru
- Page 37 and 38: Profilo 1 H NMR di urina umana
- Page 39 and 40: Profilo di siero umano Proteins + L
- Page 41 and 42: Data analysis - approach Classify N
- Page 43: PCA Unsupervised Multivariate analy
- Page 51 and 52: PCA Loadings Plot • Loadings plot
- Page 53 and 54: SIMCA Supervised learning method ba
- Page 55 and 56: OPLS OPLS method is a recent modifi
- Page 57 and 58: Targeted profiling Targeted metabol
- Page 59 and 60: Databases
- Page 61 and 62: Effetto della dieta Trimetilammina
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- Page 65 and 66: METabolomic REFerence The METREF pr
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- Page 77 and 78: Un “salto” metabolico Evoluzion
- Page 79 and 80: Celiac Disease Metabolomics Experim
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- Page 85 and 86: Celiac Disease Metabolomics Cluster
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- Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
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- Page 95 and 96: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
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- Page 103 and 104: formato Formato acetato e piruvato
- Page 105: Disponibilità di Tesi in METABOLOM
METabolomic REFerence<br />
Convex hulls of 22 donors in the three most significant PCA PCA-CA CA dimensions<br />
PCA for data<br />
reduction<br />
CA for obtain<br />
well separated<br />
clusters<br />
KNN for<br />
classification<br />
99% accuracy<br />
in montecarlo<br />
cross validation<br />
“natural” gender discrimination<br />
MALE<br />
FEMALE<br />
Assfalg, Bertini, Colangiuli, Luchinat, Schäfer, Schütz, Spraul, PNAS PNAS, , 2008 2008, , 105, 1420 1420-4