Metabolomics - CERM
Metabolomics - CERM Metabolomics - CERM
METabolomic REFerence Experimental scheme: • 22 Individuals, 11 Males & 11 Females • ≥40 urine samples each, on a period of 2-3 months • First in the morning preprandial • Collection suspended in case of illness; otherwise no restrictions • Data recording: Diet Drugs Lifestyle, general habits Smoker / No Smoker • NMR analysis: 1D 1 H spectra
Ind 1 Ind 2 METabolomic REFerence Getting a first feeling… We believe the human eye is very sensitive to differences in patterns Visual inspection suggests that it should be interesting to look for individual fingerprints by statistical analysis
- Page 15 and 16: C om p ound class N u m b er C om p
- Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
- Page 19 and 20: Medical Metabolomics Generate metab
- Page 21 and 22: Traditional Metabolite Analysis HPL
- Page 23 and 24: What’s the Difference Between Met
- Page 25 and 26: Advantages Measure multiple (10’s
- Page 27 and 28: 2 Routes to Metabolomics Two approa
- Page 29 and 30: Benefits of analyzing the metabolom
- Page 31 and 32: Advantages: Use of NMR in Non-destr
- Page 33 and 34: Raccolta e stoccaggio dei campioni
- Page 35 and 36: NMR A typical 950-MHz H NMR spectru
- Page 37 and 38: Profilo 1 H NMR di urina umana
- Page 39 and 40: Profilo di siero umano Proteins + L
- Page 41 and 42: Data analysis - approach Classify N
- Page 43: PCA Unsupervised Multivariate analy
- Page 51 and 52: PCA Loadings Plot • Loadings plot
- Page 53 and 54: SIMCA Supervised learning method ba
- Page 55 and 56: OPLS OPLS method is a recent modifi
- Page 57 and 58: Targeted profiling Targeted metabol
- Page 59 and 60: Databases
- Page 61 and 62: Effetto della dieta Trimetilammina
- Page 63 and 64: Effetto delle patologie Campioni di
- Page 65: METabolomic REFerence The METREF pr
- Page 69 and 70: METabolomic REFerence Dendrogram of
- Page 71 and 72: METabolomic REFerence An individual
- Page 73 and 74: METabolomic REFerence 2 Experimenta
- Page 75 and 76: METabolomic REFerence 2 2005 collec
- Page 77 and 78: Un “salto” metabolico Evoluzion
- Page 79 and 80: Celiac Disease Metabolomics Experim
- Page 81 and 82: Celiac Disease Metabolomics Note: b
- Page 83 and 84: Celiac Disease Metabolomics Celiac
- Page 85 and 86: Celiac Disease Metabolomics Cluster
- Page 87 and 88: Potential celiac disease Subjects:
- Page 89 and 90: Celiachia Potenziale Celiaci - Sani
- Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
- Page 93 and 94: PRODOTTI DI OSSIDAZIONE QUASI ASSEN
- Page 95 and 96: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
- Page 97 and 98: Metabolomica del latte Recente inte
- Page 99 and 100: Spettro 1 H NMR di marche diverse N
- Page 101 and 102: Formato Spettro 1 H NMR di latte di
- Page 103 and 104: formato Formato acetato e piruvato
- Page 105: Disponibilità di Tesi in METABOLOM
METabolomic REFerence<br />
Experimental scheme:<br />
• 22 Individuals, 11 Males & 11 Females<br />
• ≥40 urine samples each, on a period of 2-3 months<br />
• First in the morning preprandial<br />
• Collection suspended in case of illness; otherwise no restrictions<br />
• Data recording:<br />
Diet<br />
Drugs<br />
Lifestyle, general habits<br />
Smoker / No Smoker<br />
• NMR analysis: 1D 1 H spectra
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