Metabolomics - CERM

More documents

Recommendations

Info

$(Microsoft PowerPoint - Lezione_2.ppt [modalit\340 ... - CERM$

$(Microsoft PowerPoint - lezioneroberta.ppt [modalit\340 ... - CERM$

Our interest in metabolomics Metabolic signature of individuals Metabolic phenotype Metabolic signature of diseases • Celiac disease • tumor → metastasis (breast, colorectal) • cardiovascular risk • diabetes • pulmonary diseases • … Metabolites and biobank samples • Sensitive reporters of stability • Assess sample preparation and preanalytical procedures • …
METabolomic REFerence The METREF project Looking first at urine of healthy individuals, and developing a feeling for the intraindividual vs. interindividual variations Why? • Training • Urine samples are easy to collect • Large number of samples • Potential intrinsic value of the information
Page 1 and 2:
Metabolomics Leonardo Tenori FiorGe
Page 3 and 4:
“La metabolomica è l’ultima na
Page 5 and 6:
Metabolomica: la nuova frontiera
Page 7 and 8:
Metabonomics “…measurement of t
Page 9 and 10:
Metabolomica: alcuni obiettivi Valu
Page 11 and 12:
Metabolomica: alcuni obiettivi Scop
Page 13 and 14: The metabolome consists of what? Sm
Page 15 and 16: C om p ound class N u m b er C om p
Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
Page 19 and 20: Medical Metabolomics Generate metab
Page 21 and 22: Traditional Metabolite Analysis HPL
Page 23 and 24: What’s the Difference Between Met
Page 25 and 26: Advantages Measure multiple (10’s
Page 27 and 28: 2 Routes to Metabolomics Two approa
Page 29 and 30: Benefits of analyzing the metabolom
Page 31 and 32: Advantages: Use of NMR in Non-destr
Page 33 and 34: Raccolta e stoccaggio dei campioni
Page 35 and 36: NMR A typical 950-MHz H NMR spectru
Page 37 and 38: Profilo 1 H NMR di urina umana
Page 39 and 40: Profilo di siero umano Proteins + L
Page 41 and 42: Data analysis - approach Classify N
Page 43: PCA Unsupervised Multivariate analy
Page 51 and 52: PCA Loadings Plot • Loadings plot
Page 53 and 54: SIMCA Supervised learning method ba
Page 55 and 56: OPLS OPLS method is a recent modifi
Page 57 and 58: Targeted profiling Targeted metabol
Page 59 and 60: Databases
Page 61 and 62: Effetto della dieta Trimetilammina
Page 63: Effetto delle patologie Campioni di
Page 67 and 68: Ind 1 Ind 2 METabolomic REFerence G
Page 69 and 70: METabolomic REFerence Dendrogram of
Page 71 and 72: METabolomic REFerence An individual
Page 73 and 74: METabolomic REFerence 2 Experimenta
Page 75 and 76: METabolomic REFerence 2 2005 collec
Page 77 and 78: Un “salto” metabolico Evoluzion
Page 79 and 80: Celiac Disease Metabolomics Experim
Page 81 and 82: Celiac Disease Metabolomics Note: b
Page 83 and 84: Celiac Disease Metabolomics Celiac
Page 85 and 86: Celiac Disease Metabolomics Cluster
Page 87 and 88: Potential celiac disease Subjects:
Page 89 and 90: Celiachia Potenziale Celiaci - Sani
Page 91 and 92: ACIDO LINOLENICO REGIONE DEI METILI
Page 93 and 94: PRODOTTI DI OSSIDAZIONE QUASI ASSEN
Page 95 and 96: CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
Page 97 and 98: Metabolomica del latte Recente inte
Page 99 and 100: Spettro 1 H NMR di marche diverse N
Page 101 and 102: Formato Spettro 1 H NMR di latte di
Page 103 and 104: formato Formato acetato e piruvato
Page 105: Disponibilità di Tesi in METABOLOM
show all

Metabolomics - CERM

Create successful ePaper yourself

Delete template?

Save as template?