Metabolomics - CERM

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Since the late 1990s, such metabolomic studies have undergone an explosive explosive growth growth and and this trend is still continuing, with more than a thousand of papers published in 2010! Entries in Pubmed 1400 1200 1000 800 600 400 200 Metabonom* Metabolom* 0 1998 2000 2002 2004 2006 2008 2010 2012 Year
Metabonomics “…measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification…” Nicholson et al., 1999 What’s in a name? <strong>Metabolomics</strong> “...the complete set of metabolites/low-molecular-weight intermediates, which are context dependent, varying according to the physiology, developmental or pathological state of the cell, tissue, organ or organism…” Oliver 2002
Page 1 and 2: Metabolomics Leonardo Tenori FiorGe
Page 3 and 4: “La metabolomica è l’ultima na
Page 5: Metabolomica: la nuova frontiera
Page 9 and 10: Metabolomica: alcuni obiettivi Valu
Page 11 and 12: Metabolomica: alcuni obiettivi Scop
Page 13 and 14: The metabolome consists of what? Sm
Page 15 and 16: C om p ound class N u m b er C om p
Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
Page 19 and 20: Medical Metabolomics Generate metab
Page 21 and 22: Traditional Metabolite Analysis HPL
Page 23 and 24: What’s the Difference Between Met
Page 25 and 26: Advantages Measure multiple (10’s
Page 27 and 28: 2 Routes to Metabolomics Two approa
Page 29 and 30: Benefits of analyzing the metabolom
Page 31 and 32: Advantages: Use of NMR in Non-destr
Page 33 and 34: Raccolta e stoccaggio dei campioni
Page 35 and 36: NMR A typical 950-MHz H NMR spectru
Page 37 and 38: Profilo 1 H NMR di urina umana
Page 39 and 40: Profilo di siero umano Proteins + L
Page 41 and 42: Data analysis - approach Classify N
Page 43: PCA Unsupervised Multivariate analy
Page 51 and 52: PCA Loadings Plot • Loadings plot
Page 53 and 54: SIMCA Supervised learning method ba
Page 55 and 56: OPLS OPLS method is a recent modifi
Page 57 and 58:
Targeted profiling Targeted metabol
Page 59 and 60:
Databases
Page 61 and 62:
Effetto della dieta Trimetilammina
Page 63 and 64:
Effetto delle patologie Campioni di
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METabolomic REFerence The METREF pr
Page 67 and 68:
Ind 1 Ind 2 METabolomic REFerence G
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METabolomic REFerence Dendrogram of
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METabolomic REFerence An individual
Page 73 and 74:
METabolomic REFerence 2 Experimenta
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METabolomic REFerence 2 2005 collec
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Un “salto” metabolico Evoluzion
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Celiac Disease Metabolomics Experim
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Celiac Disease Metabolomics Note: b
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Celiac Disease Metabolomics Celiac
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Celiac Disease Metabolomics Cluster
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Potential celiac disease Subjects:
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Celiachia Potenziale Celiaci - Sani
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ACIDO LINOLENICO REGIONE DEI METILI
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PRODOTTI DI OSSIDAZIONE QUASI ASSEN
Page 95 and 96:
CARATTERIZZAZIONE GEOGRAFICA ( 1 H)
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Metabolomica del latte Recente inte
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Spettro 1 H NMR di marche diverse N
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Formato Spettro 1 H NMR di latte di
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formato Formato acetato e piruvato
Page 105:
Disponibilità di Tesi in METABOLOM
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Metabolomics - CERM

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