Metabolomics - CERM
Metabolomics - CERM Metabolomics - CERM
serum urine saliva fecal extract
Data analysis - approach Classify NMR spectrum based on its inherent patterns of peaks Identify spectral features responsible for the classification (according to physiological or pathological status) NMR spectral data processing Prepare NMR data for multivariate modeling: Spectral binning: spectra divided into regions whose areas are summed to extract peak intensities Results in a data matrix: Rows = samples/observations Columns= variables (for example, normalized peak intensities of defined bins)
- Page 1 and 2: Metabolomics Leonardo Tenori FiorGe
- Page 3 and 4: “La metabolomica è l’ultima na
- Page 5 and 6: Metabolomica: la nuova frontiera
- Page 7 and 8: Metabonomics “…measurement of t
- Page 9 and 10: Metabolomica: alcuni obiettivi Valu
- Page 11 and 12: Metabolomica: alcuni obiettivi Scop
- Page 13 and 14: The metabolome consists of what? Sm
- Page 15 and 16: C om p ound class N u m b er C om p
- Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
- Page 19 and 20: Medical Metabolomics Generate metab
- Page 21 and 22: Traditional Metabolite Analysis HPL
- Page 23 and 24: What’s the Difference Between Met
- Page 25 and 26: Advantages Measure multiple (10’s
- Page 27 and 28: 2 Routes to Metabolomics Two approa
- Page 29 and 30: Benefits of analyzing the metabolom
- Page 31 and 32: Advantages: Use of NMR in Non-destr
- Page 33 and 34: Raccolta e stoccaggio dei campioni
- Page 35 and 36: NMR A typical 950-MHz H NMR spectru
- Page 37 and 38: Profilo 1 H NMR di urina umana
- Page 39: Profilo di siero umano Proteins + L
- Page 43: PCA Unsupervised Multivariate analy
- Page 51 and 52: PCA Loadings Plot • Loadings plot
- Page 53 and 54: SIMCA Supervised learning method ba
- Page 55 and 56: OPLS OPLS method is a recent modifi
- Page 57 and 58: Targeted profiling Targeted metabol
- Page 59 and 60: Databases
- Page 61 and 62: Effetto della dieta Trimetilammina
- Page 63 and 64: Effetto delle patologie Campioni di
- Page 65 and 66: METabolomic REFerence The METREF pr
- Page 67 and 68: Ind 1 Ind 2 METabolomic REFerence G
- Page 69 and 70: METabolomic REFerence Dendrogram of
- Page 71 and 72: METabolomic REFerence An individual
- Page 73 and 74: METabolomic REFerence 2 Experimenta
- Page 75 and 76: METabolomic REFerence 2 2005 collec
- Page 77 and 78: Un “salto” metabolico Evoluzion
- Page 79 and 80: Celiac Disease Metabolomics Experim
- Page 81 and 82: Celiac Disease Metabolomics Note: b
- Page 83 and 84: Celiac Disease Metabolomics Celiac
- Page 85 and 86: Celiac Disease Metabolomics Cluster
- Page 87 and 88: Potential celiac disease Subjects:
- Page 89 and 90: Celiachia Potenziale Celiaci - Sani
serum<br />
urine<br />
saliva<br />
fecal extract
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