Metabolomics - CERM
Metabolomics - CERM Metabolomics - CERM
Genomics is “only” the start! Genomics: the complete blueprint of an individual. What do we need more? There are 6 million parts in a 747 plane. If someone shows you the blueprints of all of them one after the other, would you be able to tell how the plane looks like? Proteomics: “only” 30-40,000 proteins. However, millions of potential interactions that make an “individual”. And the analysis is still very difficult… Metabolomics: Only a few thousand metabolites. However, not negligible external variability.
Metabolomica: la nuova frontiera “Genomics and proteomics tell you what might happen, but metabolomics tells you what actually did happen” Bill Lasley - University of California, Davis “If you have a disease, it’s likely that your metabolism is going to be affected. The same is true if you get hit with a toxicant. To be honest, the diagnostic potential is staggering” Mark Viant - University of Birmingham
- Page 1 and 2: Metabolomics Leonardo Tenori FiorGe
- Page 3: “La metabolomica è l’ultima na
- Page 7 and 8: Metabonomics “…measurement of t
- Page 9 and 10: Metabolomica: alcuni obiettivi Valu
- Page 11 and 12: Metabolomica: alcuni obiettivi Scop
- Page 13 and 14: The metabolome consists of what? Sm
- Page 15 and 16: C om p ound class N u m b er C om p
- Page 17 and 18: Why 1 µM? Equals ~200 ng/mL Limit
- Page 19 and 20: Medical Metabolomics Generate metab
- Page 21 and 22: Traditional Metabolite Analysis HPL
- Page 23 and 24: What’s the Difference Between Met
- Page 25 and 26: Advantages Measure multiple (10’s
- Page 27 and 28: 2 Routes to Metabolomics Two approa
- Page 29 and 30: Benefits of analyzing the metabolom
- Page 31 and 32: Advantages: Use of NMR in Non-destr
- Page 33 and 34: Raccolta e stoccaggio dei campioni
- Page 35 and 36: NMR A typical 950-MHz H NMR spectru
- Page 37 and 38: Profilo 1 H NMR di urina umana
- Page 39 and 40: Profilo di siero umano Proteins + L
- Page 41 and 42: Data analysis - approach Classify N
- Page 43: PCA Unsupervised Multivariate analy
- Page 51 and 52: PCA Loadings Plot • Loadings plot
- Page 53 and 54: SIMCA Supervised learning method ba
Genomics is “only” the<br />
start!<br />
Genomics:<br />
the complete blueprint of an individual. What do we need more?<br />
There are 6 million parts in a 747 plane. If someone shows you the<br />
blueprints of all of them one after the other, would you be able to tell how<br />
the plane looks like?<br />
Proteomics:<br />
“only” 30-40,000 proteins.<br />
However, millions of potential interactions that make an “individual”. And the<br />
analysis is still very difficult…<br />
<strong>Metabolomics</strong>:<br />
Only a few thousand metabolites.<br />
However, not negligible external variability.
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