Metabolomics - CERM

Benefits of analyzing the
metabolome
Number of metabolites lower than number of genes and proteins in
a cell - sample complexity reduced
Although concentration of enzyme & metabolic flux may not
significantly change during a biochemical reaction, concentration
of metabolites can change significantly
Reflect more accurately functional level of a cell
Metabolic fluxes regulated not only by gene expression but also by
environmental stresses - hence worth measuring downstream
products (i.e. metabolites)
Estimated that metabolomic expts are 2x to 3x less expensive than
proteomic & transcriptomic expts