I_kongres_streszczenia.pdf

Keywords: peri-menopausal women, nutrition, bone mineral status, BMI
Introduction
Taking into consideration bones diseases, obesity is perceived as a protective factor. Women after menopause with
higher BMI have higher bone mineral density, as i.a. fat tissue takes partly over the role of the endocrine gland. It
stems from the fact that the more there is fat or/and muscles tissue in the body, the more there are estrogens circulating
in women after menopause. The protective influence of the fat tissue for obese women is connected most probably with
the increase of the bone creation or with decrease of the bone resorption, or those processes occur simultaneously.
Aim of the work
The BMI evaluation depending on bone mineral status when taking into consideration osteoporosis.
Materials and methods
The study involved 277 women aged 39-59. The measurements of body mass (kg) and height (cm) were completed
based on which the BMI (kg/m 2 ) was calculated. The evaluation of the bone mineral state was done
ultrasonographically, that is measuring the mean ultrasonic wave speed crossing the further bottoms of the fingerjoints,
using the DBM Sonic Bone Profiler Igea apparatus. Bone mineral status was expressed by the Z-score BMD
index. The analysis of the correlation between the BMI and bone mineral status was made using the ANOVA test. All
statistical calculations were made using the Statistica v.6.0 computer program, at p≤0.05.
Results
The analysis of the bone tissue state showed irregularities indicating osteopeny or osteoporosis in almost half of the
studied women. Significant differences were stated between the BMI and bone mineral status in the analyzed women’s
population (p=0,047). The lowest percentage of regular skeleton state was found in the group of women with
overweight and obesity.
Conclusion
Overweight and obesity are not factors protecting when osteoporosis risk is taken into consideration in the analyzed
women’s group.
The research was financed within the 3 P06T 03922 KBN project.
P56
OSTEOPROTEGRYNA, SRANKL, TNF-α, INTERLEUKINA-6 W PATOLOGII I REGULACJI GĘSTOŚCI
MINERALNEJ KOŚCI U KOBIET Z OTYŁOŚCIĄ
Krela-Kaźmierczak I., Łykowska-Szuber L., Linke K.
Katedra i Klinika Gastroenterologii i śywienia Człowieka AM, Poznań
Słowa kluczowe: Osteoporoza, otyłość, sRANKL, TNF-alpha
Wstęp
Otyłość jest czynnikiem protekcyjnym dla BMD, lecz mechanizm tego zjawiska pozostaje niejasny. sRANKL jest
czynnikiem stymulującym osteoklasty. Il-6 i TNF-α podwyŜszają ekspresję sRANKL a obniŜają ekspresję OPG na
osteoblastach.
Cel pracy
Ocena: Tkanki tłuszczowej Fat Mass -(FM), Masy ciała szczupłego -Lean Body Mass (LBM), Wskaźnika masy ciała –
Body Mass Index -BMI, Gęstości mineralnej kości - Bone Mineral Density (BMD), - rozpuszczalnego aktywatora
receptora jądrowego ligandu NF-kappa B - soluble Receptor Activator of Nuclear (NF)-kB Ligand sRANKL,
Osteoprotegryny - OPG, Interleukiny-6 - Il-6 i Czynnika martwicy nowotworów- Tumor Necrosis Factor -TNF-α u
kobiet otyłych.
Materiał i metody
Oceniano: FM, LBM, BMI(kg/m2) metodą bioelektrycznej impedancji -Bodystat 1500; BMD mierzono metodą
DEXA-LUNAR DPX-IQ. StęŜenie: sRANKL, OPG, Il-6i TNF-α w surowicy oznaczono metodą ELISA. Grupy
badane: I kobiety otyłe z prawidłowym BMD (n=15) w wieku średnim 39±4,9 lat II kobiety z prawidłowym BMI i z
osteoporozą: (n=15) w średnim wieku 55±7,7 lat.
Wyniki
BMI:I 30,32±3,77; II 25,3±3,46.BMD (g/cm2) L2-4: I 1,226±0,09 (T-score: 0,63±0,49), II 0,886±0,075 (T-score:–
2,54±0,65)(p