Complementary Alternative Cardiovascular Medicine

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198 Alternative Cardiovascular Medicine Table 1 Contraindications to EDTA Chelation Therapy 1. Acute coronary syndromes 2. Acute limb ischemia 3. Severe left ventricular dysfunction, with left ventricular ejection fraction < 30% 4. Angiographic indications for coronary revascularization (left main, twovessel with proximal LAD, and three-vessel with left ventricular dysfunction) 5. Serum creatinine > 2.5 mg/dL 6. Pregnancy 7. Active hepatic disease 8. Allergy to ethylene diamine tetraacetic acid patients may benefit from it. Conversely, if EDTA chelation were without clinical merit, then physicians, administrators, and regulatory authorities would be able to reject it on solid scientific evidence. The few double-blind, prospective trials that have been performed were either underpowered or methodologically flawed. The general acceptance of EDTA chelation therapy in treating CVDs will need more rigorously designed clinical studies to establish its efficacy and safety. Fortunately, a large multicenter trial Trial to Assess Chelation Therapy (TACT) has been initiated by the National Institutes of Health to assess the effects of EDTA chelation on quality of life, clinical outcomes, cost-effectiveness, and plasma markers of oxidative stress and endothelial dysfunction. Until such a trial is completed, physicians can intelligently counsel patients inquiring about EDTA chelation therapy by adhering to the guidelines presented. REFERENCES 1. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years of literature on edetate sodium chelation therapy. Ann Pharmacotherapy 1993;27:1504–1509. 2. Quan H, Ghali WA, Verhoef MJ, Norris CM, Galbraith PD, Knudtson ML. Use of chelation therapy after coronary angiography. Am J Med 2000;111:686–691. 3. Clarke NE, Sr., Clarke NE, Jr., Mosher RE. The “in vivo” dissolution of metastatic calcium. An approach to atherosclerosis. Am J Med Sci 1955;229:142–149. 4. Clarke NE. Treatment of angina pectoris with disodium EDTA. Am J Med Sci 1956;232:654–666. 5. Clarke NE, Atherosclerosis, occlusive vascular disease and EDTA. Am J Cardiol 1960;6:233. 6. Kitchell JR, Meltzer LE, Seven MJ. Potential uses of chelation methods in the treatment of cardiovascular diseases. Prog Cardiol Dis 1961;3:338–349.
Chapter 12 / Chelation Therapy and CVD 199 7. Meltzer LE, Kitchell JR, Palmon F, Jr. The long term use, side effects and toxicity of disodium ethylenediamine tetraacetic acid (EDTA). Am J Med Sci 1961;242:51–57. 8. Kitchell JR, Palmon F, Aytan N, Meltzer L. The treatment of coronary artery disease with disodium EDTA: a reappraisal. Am J Cardiol 1963;11:501–506. 9. Cranton EM, Frackelton JP. Current status of EDTA chelation therapy in occlusive arterial disease. J Holistic Med 1982;1:24. 10. Olzsewer E, Carter JP. EDTA chelation therapy: a retrospective study of 2,870 patients. J Adv Med 1989;2:137–139. 11. Chappell LT, Stahl JP. The correlation between EDTA chelation therapy and improvement in cardiovascular function: a meta-analysis. J Adv Med 1993;6:139–160. 12. Clarke NE, Sr., Clarke NE, Jr., Mosher RE. Treatment of occlusive vascular disease with disodium ethylene diamine tetraacetic acid. Am J Med Sci 1960;239:732–744. 13. Nikitina EK, Abramova MA. Treatment of atherosclerosis with Trilon B (EDTA) Kardiologiia 1972;12:137–139 14. Lamar CP. Chelation therapy for occlusive arteriosclerosis in diabetic patients. Angiology 1964;15:379–395. 15. Brucknerova O, Tulacek J. Chelates in the treatment of occlusive atherosclerosis. Vnitrni Lek 1972;18:729–735. 16. McDonagh EW, Rudolph CJ, Cheraskin E. An oculocerebrovasculometric analysis of the improvement in arterial stenosis following EDTA chelation therapy. J Holistic Med 1982;4:21–23. 17. Rudolph CJ, McDonagh EW. Effect of EDTA chelation and supportive multivitamin trace mineral supplementation on carotid circulation: case report. J Adv Med 1990;3:5–11. 19. Rudolph CJ, McDonagh EW, Barber RK. A non-surgical approach to obstructive carotid stenosis using EDTA chelation. J Adv Med 1991;4:157–166. 20. Sloth-Nielson J, Guldager B, Mouritzen C, et al. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg 1991;4:122–125. 21. Guldager B, Jelnes R, Jorgensen SJ, et al. EDTA treatment of intermittent claudication—a double-blind, placebo controlled study. J Int Med 1992;231:231–267. 22. Udvalget Vedrorenmde Videnskabelig Uredelighed (UVVU). The Committee on Scientific Dishonesty. Conclusions concerning complaints in connection with trial of EDTA versus placebo in the treatment of atherosclerosis. January 1994. 23. Van Rij AM, Solomon C, Packer SGK, Hopkins WG. Chelation therapy for intermittent claudication: a double-blind, randomized, controlled trial. Circulation 1994;90:1194–1199. 24. Knudtson ML,Wyse, GD, Galbraith PD, et al. Chelation therapy for ischemic heart disease: A randomized controlled trial. JAMA 2002;287:481–486. 25. Bolick LE, Blankenhorn DH. A quantitative study of coronary arterial calcification. Am J Path 1961;39:511. 26. Wilder L, DeJode L, Milstein SR. Mobilization of atherosclerotic plaque calcium with EDTA utilizing the isolation-perfusion principle. Surgery 1962;52:793. 27. Kindness G, Frackelton JP. Effect of ethylene diamine tetraacetic acid (EDTA) on platelet aggregation in human blood. J Adv Med 1989;2:519–530. 28. Rudolph CJ, McDonagh EW, Barber RK. Effect of EDTA chelation on serum iron. J Adv Med 1991;4:39–45. 29. Schroeder H. A practical method for the reduction of plasma cholesterol in man. J Chron Dis 1956;4:461. 30. Olwin J, Koppel J. Reduction of elevated plasma lipid levels in atherosclerosis following EDTA therapy. Proc Soc Exp Biol Med 1968;128:1137.
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Complementary and Alternative Cardi
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CONTEMPORARY CARDIOLOGY CHRISTOPHER
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© 2004 Humana Press Inc. 999 River
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vi Preface physician or other healt
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viii Contents 10 Massage Therapy an
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x Contributors ERIN L. OLIVO, PhD
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Chapter 1 / CAM and CVD 1 1 Complem
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Chapter 1 / CAM and CVD 3 patients
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Chapter 1 / CAM and CVD 5 The crite
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12 Alternative Cardiovascular Medic
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Chapter 15 / Aromatherapy and CVD 2
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Index 279 INDEX A N-Acetylcysteine
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Index 281 taurine studies, 106 Conj
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Index 283 Homeopathic medicine, see
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Index 285 funding of studies, 148 g
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Contemporary Cardiology COMPLEMENTA
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Complementary Alternative Cardiovascular Medicine

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