PS-PLLA - Www2.che.nthu.edu.tw

Synthetic routes of PS-PLLA block copolymers
O
Ph O
Ph
O N
m
PS-TEMPO-OH
Living free radical polymerization
Living ring-opening polymerization
OH
Toluene
O O
Li TEMPO-PS
O
Li
Li
Li
Li
O
Li TEMPO-PS
O O
Lithium Alkoxide Macroinitiator
OEt 2
O C
Li
O
Li
Li
Li
Li
C
Li
O O
OO
PS H OO
O
3
C
O N O
O
H
O N O
O
H
Ph O
O
P h O
O
C O [ C H C ]
2
H
n
O
Ph
O
P h m
O
*
m n n
Non-biodegradable H Biodegradable
PS-PLLA3
C CH 3
P S - P L L A
CH 3
O
N O [ C C H O ]
m
H
CH 3
+
Lin, C.-C. et al. J. Am. Chem. Soc. 2001, 123, 7973-7977.
n L-LA/ CH 2Cl 2, 0 o C
PLLA
Poly(styrene)-block-Poly(L-lactide) (PS-PLLA)
O -
O -
t-Bu
=
t-Bu
t-Bu
O- O- t-Bu