Diapositiva 1

PAML → CODEML
Models to detect positive selection acting on:
• Particular branches/lineages of a phylogeny (branch models).
• Particular codon (amino acid) sites (site-specific models).
Test for adaptive evolution in the VHL (Von Hippel-Lindau ) gene
• Dataset:
• Objective:
16 sequencies from different species
Test for sites evolving under positive
selection.
Identify sites by using empirical Bayes